α-雌二醇
| 中文名称 | α-雌二醇 |
|---|---|
| 中文同义词 | 雌甾-1,3,5(10)三烯-3,17Α-二醇;Α-雌二醇溶液, 100PPM;雌二醇 1G;3,17Α-二羟基-1,3,5(10)-雌三烯;17Α-雌二醇标准品;14-EPI雌二醇;17a-雌二醇;炔雌醇杂质L |
| 英文名称 | Estradiol |
| 英文同义词 | 1,3,5-estratriene-3,17-alpha-diol;1,3,5-Estratriene-3,17alpha-diol;17alpha-Oestradiol;3,17alpha-Dihydroxyestra-1,3,5(10)-triene;3,17-alpha-dihydroxyoestra-1,3,5(10)-triene;3,17alpha-Dihydroxyoestra-1,3,5(10)-triene;5(10)-triene-3,17-diol,(17-alpha)-estra-3;epiestradial |
| CAS号 | 57-91-0 |
| 分子式 | C18H24O2 |
| 分子量 | 272.39 |
| EINECS号 | 200-354-8 |
| 相关类别 | 抗生素、生物碱;甾体激素类;医药原料;医药原料药-科研原料;其它萜类;医药原材料;试剂盒-Elisa试剂盒;医用原料;Steroids;Intermediates & Fine Chemicals;Pharmaceuticals;APIs;化学试剂 |
| Mol文件 | 57-91-0.mol |
| 结构式 |  |
α-雌二醇 性质
| 熔点 | 176-180 °C(lit.) |
|---|---|
| 沸点 | 355.44°C (rough estimate) |
| 比旋光度 | D20 +53 to +56° (c = 0.9 in dioxane) |
| 密度 | 1.0708 (rough estimate) |
| 折射率 | 1.4800 (estimate) |
| 储存条件 | Sealed in dry,Room Temperature |
| 溶解度 | 乙醇：50 mg/mL，澄清，无色 |
| 形态 | 粉末 |
| 酸度系数(pKa) | 10.27±0.60(Predicted) |
| 颜色 | 白色略带黄色 |
| 水溶解性 | 3.9mg/L(25 ºC) |
| Merck | 14,3704 |
| CAS 数据库 | 57-91-0(CAS DataBase Reference) |
| NIST化学物质信息 | Estra-1,3,5(10)-triene-3,17alpha-diol(57-91-0) |
| EPA化学物质信息 | Estra-1,3,5(10)-triene-3,17-diol, (17.alpha.)- (57-91-0) |
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Human Endogenous Metabolite
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Alpha-Estradiol (17 alpha-Estradiol) is a 5α-reductase inhibitor, and inhibits testosterone metabolism catalyzed by 5 alpha-reductase. Alpha-Estradiol (17 Alpha-estradiol, 10 μM) attenuates LPS-induced inflammatory markers in both C57BL/6J male and female mouse embryonic fibroblast (MEF) cells, primary pre-adipocytes and differentiated 3T3-L1 adipocytes in an ERα-dependent manner, and such effects are through decreased NFκB-p65 and increased ERα protein expression.
Alpha-Estradiol (17-alpha-estradiol, 0.01, 0.1, 1 μg) significantly reduces the percentage of central avascular/total retina area of the mouse pups. Alpha-Estradiol (1 μg) markedly decreasesmalondialdehyde (MDA) levels on postnatal days (PND) 9, 13, and 17 in retinas of hyperoxia-exposed pups. Alpha-Estradiol (1 μg) also decreases the number of NADPH-oxidase-positive cells, NADPH oxidase concentration and activity in retinas of the pups. In the 1.0-μg Alpha-Estradiol-treated pups, VEGF retinal concentrations are high on PND 9 but lower on PND 14 and 17. The best effect in retinas of 1.0-μg Alpha-Estradiol-treated pups is partly reversed by ICI182780 on PND 14 and 17.
Estradiol (known as α-Estradiol or 17 α-Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture. 17α-stradiol and its selective receptor, ER-X, are not part of a cl assical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain.17-Estradiol may have enormous implications for hormone replac ement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimer disease and ischemic stroke.
安全信息
| 危险品标志 | T,Xn |
|---|---|
| 危险类别码 | 45-48-40 |
| 安全说明 | 53-45-24/25-22 |
| 危险品运输编号 | UN 2811 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS号 | KG3750000 |
| F | 8-10 |
| 海关编码 | 29372390 |
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