洋蓟素
中文名称 | 洋蓟素 |
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中文同义词 | 1,5-二咖啡酰奎宁酸(洋蓟素,洋蓟酸,菜蓟素,朝蓟素,朝鲜蓟酸,1,5-O-二咖啡酰奎宁酸);1,5-二咖啡酰奎尼酸;1,3-O-二咖啡酸酰奎宁酸;洋蓟素,洋蓟酸,菜蓟素,朝蓟素,朝鲜蓟酸,1,5-O-二咖啡酰奎宁酸;1,3-二咖啡酰奎宁酸;1,5-二咖啡酰奎宁酸;朝鲜蓟酸1,3;菜蓟素 |
英文名称 | Cynarin |
英文同义词 | 1,5-DICAFFEOYLQUINIC ACID;1,3-DICAFFEOYLQUINIC ACID;Dicaffeoylquinic Acid, 1,3-;(1R,3R,4S,5R)-1,3-Bis((3-(3,4-dihydroxyphenyl)acryloyl)oxy)-4,5-dihydroxycyclohexanecarboxylic acid;CYNARIN(ECHINACEA);CYNARIN(ARTICHOKE);CYNARIN;CINARINE |
CAS号 | 30964-13-7 |
分子式 | C25H24O12 |
分子量 | 516.45 |
EINECS号 | 214-655-7 |
相关类别 | 植物生化提取物;中药标准品;医药原料;植提;标准品;化学对照品;中药对照品;对照品,标准品;分析标准品;植物提取物;对照品;植提标准品;分析试剂标准品;标准品-对照品;标准品-中药标准品;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;标准品 -中药标准品;标准品,对照品;天然产物;生物化工;比例提取物 |
Mol文件 | 30964-13-7.mol |
结构式 |
洋蓟素 性质
熔点 | 225-227° |
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比旋光度 | D25 -59° (c = 2 in methanol) |
沸点 | 819.9±65.0 °C(Predicted) |
密度 | 1?+-.0.1 g/cm3(Predicted) |
储存条件 | Sealed in dry,2-8°C |
溶解度 | 在甲醇中可溶5mg/mL,澄清,淡黄色至黄色 |
酸度系数(pKa) | 2.58±0.50(Predicted) |
形态 | 固体 |
颜色 | 淡黄色至黄色 |
稳定性 | 吸湿性 |
LogP | 1.640 (est) |
CAS 数据库 | 30964-13-7(CAS DataBase Reference) |
Target | Value |
CD28 - CD80 interaction
() | |
Nrf2
() | |
GSH
() | |
ROS
() |
Cynarin inhibits taste receptors, making water to be sweet. It has been shown to have some pharmacological properties including hypocholesterolemic, hepatoprotective, antiviral, antibacterial, and antihistamic effects. Cynarin has marked antioxidant, anticholinergic, reducing ability, radical-scavenging, and metal-binding activities. Cynarin demonstrates 87.72% inhibition of linoleic acid lipid peroxidation at 30 mg/mL concentration. Cynarin exhibits effective DMPD + , ABTS + , O 2 - , DPPH 1 , and H 2 O 2 scavenging effects, reducing capabilities and Fe 2+ chelating effects. IC 50 and K i of cynarin for acetylcholinesterase enzyme inhibition are 243.67nM and 39.34±13.88 nM, respectively. Cynarin is a potential immunosuppressant that blocks the interaction between the CD28 of T-cell receptor and CD80 of antigen presenting cells. Cynarin blocks about 87% of the CD28-dependent "signal 2" pathway of T-cell activation under the condition of one to one ratio of T-cell and B-cell. Cynarin binds to the "G-pocket" of CD28 and thus interrupts the site of interaction between CD28 and CD80.
药理药效:具有利胆、保肝、降胆固醇作用。临床用于治疗由肝功能不足引起的各种疾病。还可作为利胆药。
安全信息
安全说明 | 24/25 |
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WGK Germany | 3 |
海关编码 | 29182900 |
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/08/19 | HY-N1412 | 1,3-Dicaffeoylquinic acid | 1 mg | 533元 | |
2024/08/19 | HY-N1412 | 洋蓟素 1,3-Dicaffeoylquinic acid | 30964-13-7 | 5mg | 1400元 |