1,1'-Biphenyl, 2-ethynyl-2'-methyl- synthesis

7synthesis methods

Product Name:1,1'-Biphenyl, 2-ethynyl-2'-methyl-
CAS Number:1449574-70-2
Molecular formula:C15H12
Molecular Weight:192.26

558-13-4 Synthesis

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7111-68-4 Synthesis

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Yield:1449574-70-2 1.02 g

Reaction Conditions:

Stage #1: carbon tetrabromidewith triphenylphosphine in dichloromethane at 0;Inert atmosphere;Corey-Fuchs Alkyne Synthesis;
Stage #2: 2'-methylbiphenyl-2-carboxaldehyde in dichloromethane at 0;Inert atmosphere;Corey-Fuchs Alkyne Synthesis;
Stage #3: with n-butyllithium in tetrahydrofuran;hexane at -78;Inert atmosphere;Corey-Fuchs Alkyne Synthesis;

Steps:

4.4 General procedure C for the synthesis of alkynes 3 [25]

General procedure: A 2.5 M n-BuLi solution of in hexane (2.5 equiv.) was added to a solution of 2’-(2,2-Dibromovinyl)biphenyl derivative, 2a-d (1.0 g, 1 equiv.) in THF (15 mL) at -78 °C. Stirring was continued at that temperature for 5 h under N₂ atmosphere. The cold mixture was quenched with water and the aqueous phase was extracted with diethyl ether (3 × 10 mL). The combined organic layers were dried over Na₂SO₄ and concentrated in vacuo before the crude product was purified by flash chromatography (heptane/ethyl acetate 98:2) to give the alkyne 3a-d.

References:

Tiruye, Hiwot M.;J?rgensen, K?re B. [Tetrahedron,2022,vol. 129,art. no. 133144]

7111-68-4 Synthesis

7111-68-4
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