1,1-Bis(4-chlorophenyl)-2,2,2-trifluoroethanol synthesis
7synthesis methods
- Product Name:1,1-Bis(4-chlorophenyl)-2,2,2-trifluoroethanol
- CAS Number:630-71-7
- Molecular formula:C14H9Cl2F3O
- Molecular Weight:321.12
Yield:630-71-7 99 %Spectr.
Reaction Conditions:
Stage #1: diethoxytrifluoromethylphosphonate;4,4'-Dichlorobenzophenonewith potassium tert-butylate in N,N-dimethyl-formamide at -40 - 20; for 1 h;
Stage #2: with hydrogenchloride in water;N,N-dimethyl-formamide at 20;
References:
Cherkupally, Prabhakar;Beier, Petr [Tetrahedron Letters,2010,vol. 51,# 2,p. 252 - 255] Location in patent:experimental part
