ChemicalBook CAS DataBase List 1,2,3,4-Tetrafluorobenzene

1,2,3,4-Tetrafluorobenzene synthesis

10synthesis methods

Product Name:1,2,3,4-Tetrafluorobenzene
CAS Number:551-62-2
Molecular formula:C6H2F4
Molecular Weight:150.07

1201-31-6 Synthesis

1201-31-6
396 suppliers
$10.00/5g

551-62-2
234 suppliers
$10.00/1g

Yield:551-62-2 94.4%

Reaction Conditions:

with ammonia;copper in water at 240; for 1.25 h;Temperature;Reagent/catalyst;

Steps:

15
300 g was added to a 500 mL intermittent high pressure reaction kettleAmmonia concentration of 5g / L aqueous ammonia solution, 50g 2, 3, 4, 5-tetrafluorobenzoic acid and 1.67 g of copper powder, Heating to 240 ° C decarboxylation reaction 1. 25h; decarboxylation reaction is completed, Open the exhaust valve pressure relief, recovery of ammonia inside the kettle; cooling to room temperature, The organic phase and the aqueous phase were obtained by the separation of the filtrate and the filtrate. After the organic phase was distilled 1,2,3,4-tetrafluorobenzene 36. 5 g,was obtained by distillation. The purity of the product by HPLC was 99.1% The yield was 94.4%.

References:

Zhejiang Chemical Industry Institute Technology Co., Ltd;Zhejiang University;Fu, Jie;Mo, Jing;Lyu, Xiuyang;XU, Weiguo CN105732302, 2016, A Location in patent:Paragraph 0047; 0048

FullText

652-03-9 Synthesis