1,2,3,4-TETRAHYDRO-6-METHOXY-1-NAPHTHALENAMINE synthesis
- Product Name:1,2,3,4-TETRAHYDRO-6-METHOXY-1-NAPHTHALENAMINE
- CAS Number:52373-02-1
- Molecular formula:C11H15NO
- Molecular Weight:177.24
120342-64-5
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52373-02-1
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Yield:52373-02-1 90%
Reaction Conditions:
with palladium on activated charcoal;hydrogen in methanol; for 3 h;
Steps:
I
To a solution of Compound 47c (l-azido-6-methoxy-l,2,3,4-tetrahydronaphthalene) (0.14 g, 0.66 mmol) in MeOH (50 mL) was added Pd/C (0.03 g). After addition, the reaction mixture was stirred under Eb for 3 hours.[0509] After reaction was completed, the solvent was removed under reduced pressure. Pd/C was filed off through a pad of celite and washed with EtOAc. The filtrate was concentrated in vacuo to afford Compound 47d (6-methoxy-l,2,3,4-tetrahydronaphthalen-l-amine) (0.11 g, 0.59 mmol, yield 90%).
References:
WO2020/205455,2020,A1 Location in patent:Paragraph 0063; 0503; 0508; 0509
1078-19-9
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52373-02-1
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1730-48-9
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52373-02-1
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16821-32-2
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52373-02-1
38 suppliers
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