1,2,3,4-tetrahydro-Phenazine synthesis
- Product Name:1,2,3,4-tetrahydro-Phenazine
- CAS Number:4829-73-6
- Molecular formula:C12H12N2
- Molecular Weight:184.24
Yield: 74%
Reaction Conditions:
with palladium on activated charcoal;hydrogen;potassium carbonate in para-xylene at 120; under 760.051 Torr; for 12 h;Schlenk technique;
Steps:
1 Example 1
In a schlenk tube, add 0.25 mmol of 2-nitroaniline, 0.35 mmol of o-diphenol, 0.0075 mmol of palladium on carbon, 0.05 mmol of potassium carbonate, 1.5 ml of para-xylene,After stirring the reaction for 12 hours at 120 ° C and H2 (the pressure of hydrogen used is one atmosphere), stop heating and stirring, cool to room temperature, and remove the solvent by rotary evaporation under reduced pressure.It is then separated and purified by column chromatography to obtain the target product.The volume ratio of the column chromatography eluent used was a petroleum ether: ethyl acetate mixed solvent with a volume ratio of 15: 1, and the yield was 74%.
References:
Wuyi University;Xie Feng;Zhang Min;Li Yibiao;Ma Weilin;He Jianwen;Gao Shuwen CN110776472, 2020, A Location in patent:Paragraph 0042-0045
