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ChemicalBook CAS DataBase List 1,2,4,5-Tetrazine,1,4-dihydro-3,6-di-2-pyridinyl-
1671-86-9

1,2,4,5-Tetrazine,1,4-dihydro-3,6-di-2-pyridinyl- synthesis

3synthesis methods
-

Yield:-

Reaction Conditions:

with hydrazine hydrate at 90;Inert atmosphere;

Steps:

1

2-Cyanopyridine (10.00 g, 96.0 mmol) and hydrazine hydrate (15.1 g; 300 mmol) were stirred overnight at 90° C. in an inert atmosphere. The turbid mixture was cooled to room temperature, filtered, and the residue was subsequently washed with water (20 mL) and ethanol (20 mL), and dried in vacuo to yield the crude dihydrotetrazine 1 as an orange solid (7.35 g; 65%).

References:

US2016/106859,2016,A1 Location in patent:Paragraph 0191