ChemicalBook CAS DataBase List 1-(2,4,5-trichlorophenyl)ethan-1-one

1-(2,4,5-trichlorophenyl)ethan-1-one synthesis

7synthesis methods

Product Name:1-(2,4,5-trichlorophenyl)ethan-1-one
CAS Number:13061-28-4
Molecular formula:C8H5Cl3O
Molecular Weight:223.48

75-36-5 Synthesis

75-36-5
559 suppliers
$17.92/100G

120-82-1 Synthesis

120-82-1
302 suppliers
$10.00/25g

13061-28-4
43 suppliers
$48.00/100mg

Yield: 82%

Reaction Conditions:

with aluminum (III) chloride at 20; for 3 h;

Steps:

4.1 2,4,5-Trichloroacetophenone (4)
To a stirred mixture of 1,2,4-trichlorobenzene (18.2 g,100mmol) and anhydrous aluminum trichloride (33.4 g,250mmol), acetyl chloride (11.8 g, 150mmol) was dropwiseadded at room temperature. The reaction mixturewas gradually heated to 120-125°C (oil bath) and maintainedat this temperature for 3h. The resulting viscousmixture was cautiously poured onto ice-water (125mL), and the aqueous mixture was extracted with dichloromethane(3×70 mL). The combined organic extractswere dried (MgSO4), evaporated, and the residue wasdistilled under reduced pressure to give a colorless liquidwhich solidified upon standing at room temperature.Yield: 15.6 g (82%); m. p. 43-45°C, b. p. 135°C/6mmHg (lit.[29]: m.p. 47°C; lit. [30]: m. p. 44-46°C; lit. [31]: 45.5-46°C,b. p. 114-116°C/2mmHg).

References:

Barhoumi, Lina M.;El-Abadelah, Mustafa M.;Sabri, Salim S.;Voelter, Wolfgang [Zeitschrift fur Naturforschung, B: Chemical Sciences,2017,vol. 72,# 5,p. 369 - 375]

50-82-8 Synthesis