1-(2-bromoethoxy)-2-isopropylbenzene synthesis

Yield: 74%

Reaction Conditions:

with potassium carbonate;potassium iodide in acetone at 60;

Steps:

9.2.1. General procedure for the synthesis of (aryloxyl)ethylbromides (4-6)
General procedure: A solution of 1,2-dibromoethane (0.08 mol) in 40 ml of acetone was added dropwise into the mixture of respective phenol (0.02 mol) and K2CO3 (0.04 mol) in 30 ml of acetone. Subsequently, a catalytic amount of KI (0.3 mmol) was added and the resulting mixture was stirred at 60 C for 24-72 h. After the completion ofthe reaction the inorganic residues were filtrated off and organic mixture was concentrated under vacuum. The obtained crude product was purified on silica gel with AcOEt/hexane as eluting system.

References:

Canale, Vittorio;Kurczab, Rafał;Partyka, Anna;Satała, Grzegorz;Słoczyńska, Karolina;Kos, Tomasz;Jastrzębska-Więsek, Magdalena;Siwek, Agata;Pękala, Elzbieta;Bojarski, Andrzej J.;Wesołowska, Anna;Popik, Piotr;Zajdel, Paweł [Bioorganic and Medicinal Chemistry,2016,vol. 24,# 2,p. 130 - 139] Location in patent:supporting information