1,2-dichloro-4-(trifluoroMethoxy)benzene synthesis
1synthesis methods
- Product Name:1,2-dichloro-4-(trifluoroMethoxy)benzene
- CAS Number:151276-10-7
- Molecular formula:C7H3Cl2F3O
- Molecular Weight:231
Yield:151276-10-7 150 mg
Reaction Conditions:
Stage #1: m,p-dichloroanilinewith tetrafluoroboric acid;tert.-butylnitrite in ethanol at 0 - 20; for 1 h;Schlenk technique;
Stage #2: silver(I) trifluoromethoxide in acetonitrile at -40 - 20;
References:
Yang, Yu-Ming;Yao, Jian-Fei;Yan, Wei;Luo, Zhuangzhu;Tang, Zhen-Yu [Organic Letters,2019,vol. 21,# 19,p. 8003 - 8007] Location in patent:supporting information