1-(2-Hydroxy-2-phenylethyl)pyrrolidine synthesis
- Product Name:1-(2-Hydroxy-2-phenylethyl)pyrrolidine
- CAS Number:5407-61-4
- Molecular formula:C12H17NO
- Molecular Weight:191.27
Yield:5407-61-4 99%
Reaction Conditions:
with acetic acid in water at 20; for 0.5 h;
Steps:
20 Preparation of Compound 1-6
Add styrene oxide (360mg, 3.00mmol), pyrrolidine (224mg, 3.15mmol), water (22mg, 1.20mmol) and acetic acid (18mg, 0.30mmol) to the reaction flask with agitating magnet, and react at room temperature for 0.5 hour,After the reaction was monitored by TLC, the reaction solution was concentrated using a rotary evaporator to obtain compound 1-6 (568 mg) as a yellow oil with a yield of 99%.
References:
CN110885292,2020,A Location in patent:Paragraph 0129-0133
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