1-(2-(Methylsulfonyl)phenyl)ethanone synthesis
- Product Name:1-(2-(Methylsulfonyl)phenyl)ethanone
- CAS Number:3323-76-0
- Molecular formula:C9H10O3S
- Molecular Weight:198.24
Yield:3323-76-0 95%
Reaction Conditions:
with copper(l) iodide in dimethyl sulfoxide at 100;Inert atmosphere;
Steps:
A-3.1A Step 1A: Preparation of 2-bromo-1-(2-(methylsulfonyl)phenyl) ethan-1-one
A mixture of 1 -(2-iodophenyl) ethan-l-one (l.Og, 4.06 mmol), sodium methanesulfunate (0.83g, 8.12 mmol) and copper iodide (77mg, 0.4 mmol) in 10 mL of DMSO was heated to 100 °C under argon. The cooled mixture was partitioned by EA and water. The organic layer was separated, and the aqueous layer was extracted with EA twice. The combined organic layers were washed with brine, dried over MgS04, and concentrated in vacuo to afford the product, l-(2-(methylsulfonyl)phenyl) ethan-l- one, which is yellow solid with a yield of 0.77g (95%).
References:
WO2019/246343,2019,A1 Location in patent:Paragraph 0148-0150
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