1-(2-NITROPHENYL)PIPERAZINE HYDROCHLORIDE synthesis
- Product Name:1-(2-NITROPHENYL)PIPERAZINE HYDROCHLORIDE
- CAS Number:6270-12-8
- Molecular formula:C10H14ClN3O2
- Molecular Weight:243.69
59084-06-9
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$15.00/1g
6270-12-8
16 suppliers
$60.00/500mg
Yield:6270-12-8 86%
Reaction Conditions:
with hydrogenchloride in water;ethyl acetate at 20; for 0.25 h;
Steps:
4 Example 4: Preparation of 1 -(2-nitrophenyl)piperazine hydrochloride (llla.HCI)
To a solution Ilia (13.2 g, 63.7 mmol) in EtOAc (100 mL) at room temperature 37% HCI (5 mL) was added. Obtained mixture was stirred at room temperature for 15 min, then precipitate was filtered off, washed with EtOAc (2 x 20 mL) and dried to afford 1 -(2-nitrophenyl)piperazine hydrochloride llla.HCI as yellow powder (13.8 g, 86% yield): H NMR (DMSO-c 5, 500 MHz) δ 3.15 (m, 4H), 3.24 (m, 4H), 7.22 (m, 1 H), 7.39 (m, 1 H), 7.64 (m, 1 H), 7.88 (dd, J = 1.5, 8.1 Hz, 1 H), 9.57 (br s, 2H).
References:
WO2015/107057,2015,A1 Location in patent:Page/Page column 15
88-73-3
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$16.00/25g
6270-12-8
16 suppliers
$60.00/500mg