1,3,3-Trimethyl-5-oxocyclohexanecarboxylic acid synthesis
- Product Name:1,3,3-Trimethyl-5-oxocyclohexanecarboxylic acid
- CAS Number:91057-32-8
- Molecular formula:C10H16O3
- Molecular Weight:184.23
7027-11-4
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91057-32-8
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Yield:91057-32-8 96.5%
Reaction Conditions:
with hydrogenchloride;waterReflux;
Steps:
14
The Intermediate XXXIX, l,3,3-trimethyl-5-oxo-cyclohexanecarboxylic acid, was made from XXVI by following procedure. The solution of 10.2 g of XXVI (61.7 mmol) in 100 mL of conc. HC1 was heated to reflux overnight with stirring. When the reaction was complete, the solution was neutralized to pH = 3 with NaOH (3N), and the precipitate was collected, washed with water and dried in vacuo to give 11.0 g of XXXIX as white solid (96.5 % yield). 1H NMR (CDC13, 400MHz), 2.95 (d, 1H, J= 14.4 Hz), 2.32 (d, 1H, J= 14.4 Hz), 2.17 (s, 2H), 2.05 (d, 1H, J= 14.8 Hz), 1.64 (d, 1H, J= 14.4 Hz), 1.38 (s, 3H), 1.07 (s, 3H), 0.90 (s, 3H).
References:
WO2011/94953,2011,A1 Location in patent:Page/Page column 72-73
78-59-1
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124-38-9
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91057-32-8
9 suppliers
$367.00/1g
78-59-1
604 suppliers
$11.00/25g
91057-32-8
9 suppliers
$367.00/1g
93257-33-1
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91057-32-8
9 suppliers
$367.00/1g