1-(3,4-dimethylphenyl)-2-methylpropan-1-one synthesis
- Product Name:1-(3,4-dimethylphenyl)-2-methylpropan-1-one
- CAS Number:68884-85-5
- Molecular formula:C12H16O
- Molecular Weight:176.2548
Yield:-
Reaction Conditions:
aluminum (III) chloride in water at 0 - 5; for 3 h;Friedel-Crafts reaction;
Steps:
13
In a nitrogen atmosphere, 213.1 g (2.0 mol) of isobutyryl chloride and 400 g of o-xylene are introduced into a 1.5 litre reaction flask. The solution is cooled to 5 - 0°C. Then, over about three hours, 293.3 g (2.2 mol) of aluminium chloride are added in small portions at 0 - 5°C. After the evolution of HCI gas has ceased, the reaction is checked using GC. The dark-red reaction solution is then poured into ice and water and stirred to complete the reaction. The two phases are separated in a separating funnel. The organic phase is washed with water and is then concentrated using a vacuum rotary evaporator. The last remnants of solvent are removed under a high vacuum. 329.1 g of faintly yellowish oil remain behind. The product is checked using GC and a 1H NMR spectrum. The product, 1-(3,4-dimethyl-phenyl)-2-methyl- propan-1-one, is used directly in the next reaction.
References:
WO2005/100292,2005,A1 Location in patent:Page/Page column 46
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