ChemicalBook CAS DataBase List 1,3,5-Benzenetricarboxaldehyde

1,3,5-Benzenetricarboxaldehyde synthesis

11synthesis methods

Product Name:1,3,5-Benzenetricarboxaldehyde
CAS Number:3163-76-6
Molecular formula:C9H6O3
Molecular Weight:162.14

4464-18-0 Synthesis

4464-18-0
140 suppliers
$24.00/1g

3163-76-6
182 suppliers
$41.00/200MG

Yield:3163-76-6 100%

Reaction Conditions:

with 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione in tert-butyl alcohol; for 5 h;Reflux;

Steps:

1

Benzene-1,3,5-triyltrimethanol (400 mg, 2.38 mmol) was suspended in 8 ml of tBuOH, and IBX (4.00 g, 14.27 mmol, 6 equiv) was added. The mixture was heated to reux and stirred for 5h. The suspension was cooled to rt and the solids were filtered off, and subsequently washed with CH2Cl2. The clear liquid was evaporated to dryness, yielding the tri-aldehyde as white powder (385 mg, 2.38 mmol, quant). 1H NMR (500 MHz, Chloroform-d) 8 10.21 (s, 3H), 8.64 (s, 3H). 130 NMR (126 MHZ, CDCl3) 6 189.78, 137.80, 134.76.

References:

WO2018/106112,2018,A1 Location in patent:Page/Page column 66

18226-42-1 Synthesis