1-(3,5-DiMethyl-pyrazol-1-yl)-ethanone synthesis

10synthesis methods

Product Name:1-(3,5-DiMethyl-pyrazol-1-yl)-ethanone
CAS Number:10199-63-0
Molecular formula:C7H10N2O
Molecular Weight:138.1671

1068-57-1 Synthesis

1068-57-1
379 suppliers
$6.00/5g

123-54-6 Synthesis

123-54-6
559 suppliers
$10.00/25ml

10199-63-0
16 suppliers
$45.00/25mg

Yield: 98%

Reaction Conditions:

in neat (no solvent) at 120; for 0.166667 h;Microwave irradiation;

Steps:

3.1.General procedure for the synthesis of pyrazoles and diazepines
General procedure: The hydrazine/hydrazide/o-phenylenediamine (0.5 mmol) and 1,3-diketone (0.55 mmol) were mixed in a closed microwave tube and subjected to microwave irradiation on a CEM Discover SP microwave system in standard mode at 120 C for 5-20 min. Upon completion of the reaction, the crude product may be purified by passing through silica gel column eluting with 20% ethyl acetate in hexane to afford the pure products. The characterization data of the synthesized compounds are in agreement with earlier reported data (ESI).

References:

Vaddula, Buchi Reddy;Varma, Rajender S.;Leazer, John [Tetrahedron Letters,2013,vol. 54,# 12,p. 1538 - 1541] Location in patent:supporting information

67-51-6 Synthesis