1,3-Bis(4-aMinophenoxy)benzene synthesis
- Product Name:1,3-Bis(4-aMinophenoxy)benzene
- CAS Number:2479-46-1
- Molecular formula:C18H16N2O2
- Molecular Weight:292.33
13118-94-0
2479-46-1
GENERAL METHOD: A mixture of 1,3-bis(4-nitrophenoxy)benzene (1.8 g, 5.1 mmol) with 10% Pd/C (0.2 g) in methanol (70 mL) was subjected to a hydrogen atmosphere and stirred at room temperature overnight. Upon completion of the reaction, the reaction mixture was treated by diafiltration, followed by addition of water (50 mL) to the filtrate and extraction with dichloromethane three times (3 x 50 mL). The organic layers were combined, washed with brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by column chromatography to afford the target product 1,3-bis(4'-aminophenoxy)benzene as a brown solid in 56.0%, 55.0% and 69.0% yields.
13118-94-0
15 suppliers
$28.60/10mg
2479-46-1
296 suppliers
$7.00/10g
Yield:2479-46-1 55%
Reaction Conditions:
with palladium 10% on activated carbon;hydrogen in methanol at 20;Inert atmosphere;Schlenk technique;
Steps:
2.2.1.1 Synthesis of 1c-3c
General procedure: The mixture of compound 1b, 2b or 3b (1.8g, 5.1mmol) and Pd/C (10%, 0.2g) was stirred in methanol (70mL) for overnight under an hydrogen atmosphere at room temperature. After completion of present reaction, the mixture was processed by suction filtration, and then added 50mL water to the resulting filtrate, extracted with dichloromethane three times (3×50mL). The combined organic layers were washed with brine, dried (Na2SO4), and concentrated in vacuo. The crude product was purified by column chromatography, affording the expected brown solid products 1c-3c in a yield of 56.0%, 55.0% and 69.0% respectively.
References:
Chen, Zhao;Li, Zheng;Yang, Lan;Liang, Jinhua;Yin, Jun;Yu, Guang-Ao;Liu, Sheng Hua [Dyes and Pigments,2015,vol. 121,p. 170 - 177]
108-46-3
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2479-46-1
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100-00-5
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2479-46-1
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350-46-9
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$10.60/1gm:
2479-46-1
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$7.00/10g
350-46-9
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$10.60/1gm:
108-46-3
794 suppliers
$10.00/10g
2479-46-1
296 suppliers
$7.00/10g