1-(3-Bromopyridin-2-yl)piperazine synthesis
- Product Name:1-(3-Bromopyridin-2-yl)piperazine
- CAS Number:87394-56-7
- Molecular formula:C9H12BrN3
- Molecular Weight:242.12
110-85-0
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$5.00/5G
52200-48-3
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$11.00/1g
142-64-3
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$11.00/25g
87394-56-7
32 suppliers
$157.00/1g
Yield:87394-56-7 71%
Reaction Conditions:
at 190; for 1 h;
Steps:
26
Add 3-bromo-2-chloro-pyridine (10.08 g, 52.4 mmol) to piperazine (45 g) and piperazine dihydrochloride (83.4 g). Heat the mixture to 190 0C with stirring for one hr.. Allow the mixture to cool to about 80 0C then pour the material into water and extract 5 times with DCM. Dry the solution (sodium sulfate), filter and concentrate. Purify using silica gel chromatography, eluting with 15:85 methanol (with 2 M ammonia) : DCM to give l-(3-bromo-pyridin-2-yl)-piperazine as a white solid (8.98 g, 71%).
References:
WO2008/141020,2008,A1 Location in patent:Page/Page column 48
52200-48-3
349 suppliers
$11.00/1g
87394-56-7
32 suppliers
$157.00/1g
110-85-0
553 suppliers
$5.00/5G
52200-48-3
349 suppliers
$11.00/1g
87394-56-7
32 suppliers
$157.00/1g
110-85-0
553 suppliers
$5.00/5G
13534-89-9
309 suppliers
$6.00/1g
87394-56-7
32 suppliers
$157.00/1g