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Important pharmaceutical intermediates Anthelmintic Chemical Properties Uses production method Category Toxicity grading Acute oral toxicity Data Skin irritation Hazardous characteristics Flammability and hazardous characteristics Storage characteristics Extinguishing agent Professional standards
Chemical Name:
Molecular Formula:
Formula Weight:
MOL File:

Piperazine Properties

Melting point:
109-112 °C(lit.)
Boiling point:
146 °C
1,1 g/cm3
vapor pressure 
0.8 mm Hg ( 20 °C)
refractive index 
Flash point:
65 °C
storage temp. 
Store in dark!
H2O: 0.1 M at 20 °C, clear, colorless
9.83(at 23℃)
Crystalline Flakes
White to slightly yellow
11.0-12.5 (25℃, 0.1M in H2O)
explosive limit
Water Solubility 
150 g/L (20 ºC)
Air Sensitive & Hygroscopic
Stable. Hygroscopic. Light sensitive. Flammable. Incompatible with strong oxidizing agents.
CAS DataBase Reference
110-85-0(CAS DataBase Reference)
NIST Chemistry Reference
EPA Substance Registry System
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  C,Xn
Risk Statements  34-42/43-52/53-62-52-63
Safety Statements  22-26-36/37/39-45-61
RIDADR  UN 2579 8/PG 3
WGK Germany  1
RTECS  TK7800000
Hazard Note  Harmful/Corrosive
HazardClass  8
PackingGroup  III
Hazardous Substances Data 110-85-0(Hazardous Substances Data)
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H314 Causes severe skin burns and eye damage Skin corrosion/irritation Category 1A, B, C Danger P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled Sensitisation, respiratory Category 1 Danger P261, P285, P304+P341, P342+P311,P501
H361 Suspected of damaging fertility or the unborn child Reproductive toxicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
Precautionary statements:
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P284 Wear respiratory protection.
P310 Immediately call a POISON CENTER or doctor/physician.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

Piperazine price More Price(39)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.07325 Piperazine anhydrous for synthesis 110-85-0 1EA $22.25 2017-11-08 Buy
Sigma-Aldrich 1541601 Piperazine United States Pharmacopeia (USP) Reference Standard 110-85-0 200mg $348 2018-11-13 Buy
TCI Chemical P0446 Piperazine Anhydrous >98.0%(GC)(T) 110-85-0 25g $16 2017-12-01 Buy
TCI Chemical P0446 Piperazine Anhydrous >98.0%(GC)(T) 110-85-0 500g $44 2017-12-01 Buy
Alfa Aesar A15049 Piperazine, anhydrous, 99% 110-85-0 100g $24.1 2018-11-13 Buy

Piperazine Chemical Properties,Uses,Production

Important pharmaceutical intermediates

Piperazine is an important pharmaceutical intermediate, is mainly used for the production of anthelmintic piperazine phosphate, piperazine citrate and fluphenazine, strong pain, rifampicin, adipic acid piperazine, piperazine guanidine methyl tetracycline, quinoline piperazine phosphate, piperazine thiazole nitrate, enoxacin, hydroxyzine hydrochloride, trifluoperazine, diethylcarbamazine citrate, cinnarizine, flunarizine, decloxizine strong carbamazepine, prednisolone sodium phosphate, dexamethasone sodium phosphate, PPA, norfloxacin, ciprofloxacin, easy to cough piperazine, a piperazine Lee vancomycin, trimethoprim-triazine and other drugs. It is Also used for the production of surfactants products such as wetting agents, emulsifying agents,and dispersing agents ,and the production of plastic additives such as antioxidants, preservatives, stabilizers and rubber additives. It is derived from Dichloroethane by alcohol solution of ammonia.
The structural formula of piperazine
Figure 1 The structural formula of piperazine.


Piperazine is a safe and effective anti-roundworm and pinworm medicine, China's "Veterinary Pharmacopoeia" collection contains as piperazine citrate and phosphoric acid piperazine, the product can make roundworm muscle paralysis, so insects body can not be attached to the host intestinal wall and excreted with the feces. Piperazine mechanism is that it is capable of blocking cholinergic receptors at the neuromuscular junction, thereby preventing excitatory effects transmission of nerve impulses and acetylcholine. No excitement before the worm paralysis phenomenon, it is more secure. After oral ,it is rapidly absorbed by the gastrointestinal tract, it is metabolized in the body part, the rest is excreted by the kidneys. Its various salts in solution have become piperazine hexahydrate, absorption and excretion are basically the same, but the rate of excretion is of large individual differences. It is Clinically used for intestinal ascariasis, incomplete intestinal obstruction due to roundworm or early biliary ascariasis , it is also used for pinworm infection.
Various salts of piperazine ( more stable than piperazine) belong to low toxicity, efficient drive roundworm medicine, in addition to roundworms, also having impact on Oesophagostomum, pointed filaria , it has been widely used in veterinary clinic. Deworming effect of piperazine, is anticholinergic-like effect on neuromuscular joints in roundworms, thereby blocking the transmission of nerve impulses; while the worms function of producing succinic acid is also blocked, resulting in parasite paralysis, losing the ability to host attached to the intestinal wall, and by peristalsis is excreted with the feces. Piperazine and its salts can be quickly absorbed from the gastrointestinal tract, part of the metabolism in tissues (30% to 40%) the rest of the urinary excretion.
Piperazine has excellent insecticide effect on Ascaris and Oesophagostomum ,it is a common drive roundworm medication, once having a 100% dispel effect. But it has limited role in the larvae , the medication should be 1 times more after 2 months.
The above information is edited by the chemicalbook of Tian Ye.

Chemical Properties

Piperazine is a white crystalline, m.p.108~110 ℃, b.p.145~146 ℃, hygroscopic, soluble in water and ethanol, insoluble in ether, the aqueous alkaline reaction. piperazine is Usually as a commodity piperazine hexahydrate.Piperazine hexahydrate(CAS [142-63-2]) is a white crystalline, hygroscopic, m.p.44~45 ℃, b.p.145~156 ℃, soluble in water and ethanol, insoluble in ether.


It is mainly used for the production of anthelmintic piperazine phosphate, piperazine citrate.Piperazine hexahydrate is dissolved in ethanol, piperazine acetic acid is precipitated by adding glacial acetic acid stirring and cooling , it is used in the synthesis of steroids prednisolone sodium phosphate. Piperazine hexahydrate reacts with acetic anhydride to prepare intermediate acetyl piperazine of anthelmintic piperazine nitro thiazole .

production method

The preparation method is using chloroethanol as raw material, obtainning after ammonification, cyclization. The process is making chlorine ethanol and ammonium hydroxide heated in an autoclave to ammonia pressure of 441 kPa, the reaction is stirred for 5h, recover excess ammonium hydroxide aqueous solution, obtain amino alcohol. Quantitative hydrochloric acid is added with stirring, concentrate under reduced pressure to a semi-paste ethanolamine hydrochloride concentrate , heat and get rid of water to 150 ℃, add prior molten paraffin good, and then continue to heat up to 260 ℃, holding (260 ± 2) ℃ for 12h , filtere to remove the paraffin, to obtain hydrochloride piperazine. Piperazine hydrochloride, solid sodium hydroxide, water are added to the reaction vessel and stirred 1.5h, excrete ammonia, and then heat to 130~140 ℃, distill piperazine hexahydrate solution, the residue is filtered, PIPERAZINE HEXAHYDRATE solution is chilled to 8 ℃, centrifugal rejection filter piperazine hexahydrate, piperazine is obtained by piperazine hexahydrate dehydration. Reaction equation as: ClCH2CH2OH + NH4OH → NH2CH2CH2OH · HCl + H2O


corrosive materials

Toxicity grading


Acute oral toxicity

rat LD50: 1900 mg/kg; Oral-Mouse LD50: 600 mg/kg

Data Skin irritation

rabbit 500 mg Mild; Eyes-rabbit 0.25 mg/24 hours of severe

Hazardous characteristics

explosive when mixed with air

Flammability and hazardous characteristics

Combustible; decomposition of toxic nitric oxide gas in case of thermal

Storage characteristics

Treasury ventilation low-temperature drying; and stored separately from acid

Chemical Properties


Extinguishing agent

Water spray, dry powder, carbon dioxide, alcohol-resistant foam


Labelled Piperazine


keratolytic, antiseborheic


ChEBI: An azacycloalkane that consists of a six-membered ring containing two nitrogen atoms at opposite positions.

Professional standards

TWA 1 mg/m³; STEL 5 mg/m

brand name

Pincets (Marion Merrell Dow); Pinsirup (Marion Merrell Dow).

General Description

Needle-like white or colorless crystals. Shipped as a solid or suspended in a liquid medium. Very corrosive to skin, eyes and mucous membranes. Solid turns dark when exposed to light. Flash point 190°F. Used as a corrosion inhibitor and as an insecticide.

Air & Water Reactions

Flammable. Absorbs water and carbon dioxide from air. Soluble in water.

Reactivity Profile

1,4-Diazacyclohexane neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Absorbs carbon dioxide from the air, which can cause dry crystals to seem to melt. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrides. 1,4-Diazacyclohexane is sensitive to light; 1,4-Diazacyclohexane absorbs water and carbon dioxide from air. 1,4-Diazacyclohexane may be corrosive to aluminum, magnesium and zinc. .

Health Hazard

TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.

Contact allergens

Piperazine is contained in pyrazinobutazone, an equimolar salt of piperazine and phenylbutazone. Among occupational cases, most were reported in the pharmaceutical industry or laboratory workers, in nurses, and in veterinarians.

Purification Methods

Piperazine crystallises from EtOH or anhydrous *benzene and is dried at 0.01mm. It can be sublimed under vacuum and purified by zone melting. The hydrochloride has m 172-174o (from EtOH), and the dihydrochloride crystallises from aqueous EtOH and has m 318-320o (dec, sublimes at 295-315o). The picrate has m ~200o, and the picrolonate crystallises from dimethylformamide ( m 259-261o). [Beilstein 23 H 4, 23 I 4, 23 II 3, 23 III/IV 15, 23/1 V 30.]

Piperazine Preparation Products And Raw materials

Raw materials

Preparation Products

Piperazine Suppliers

Global( 307)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 China 1465 55
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 China 19954 60
Henan DaKen Chemical CO.,LTD.
+86-371-55531817 CHINA 22119 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 20795 55
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32764 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682; +8618874586545 CHINA 548 55
Jiangsu Qingquan Chemical Co., Ltd.
+86-571-86589381/86589382/86589383 CHINA 137 55
career henan chemical co
+86-371-86658258 CHINA 10011 58
Credit-Chem Co., Ltd. 400-821-5857 021-64326257
021-64393586 QQ;2798200800 China 5273 58
Spectrum Chemical Manufacturing Corp. 021-67601398,18616765336,QQ:3475911745
021-57711696 China 9821 60

View Lastest Price from Piperazine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-07-24 Piperazine
US $23.00 / KG 50KG 99% 20T

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