1-(3-chloro-5-(trifluoromethyl)phenyl)piperazine synthesis
- Product Name:1-(3-chloro-5-(trifluoromethyl)phenyl)piperazine
- CAS Number:346729-48-4
- Molecular formula:C11H12ClF3N2
- Molecular Weight:264.6746
928783-85-1
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Yield:-
Steps:
Multi-step reaction with 2 steps
1: sodium tertiary butoxide; tris-(dibenzylideneacetone)dipalladium(0); biphenyl-2-yl-di-tert-butyl-phosphane / toluene / 110 °C / Inert atmosphere
2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
References:
Foley, Timothy L.;Rai, Ganesha;Yasgar, Adam;Daniel, Thomas;Baker, Heather L.;Attene-Ramos, Matias;Kosa, Nicolas M.;Leister, William;Burkart, Michael D.;Jadhav, Ajit;Simeonov, Anton;Maloney, David J. [Journal of Medicinal Chemistry,2014,vol. 57,# 3,p. 1063 - 1078]
