1-(3-CHLOROPYRIDIN-2-YL)PIPERAZINE synthesis
- Product Name:1-(3-CHLOROPYRIDIN-2-YL)PIPERAZINE
- CAS Number:87394-55-6
- Molecular formula:C9H12ClN3
- Molecular Weight:197.66
683240-45-1
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87394-55-6
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Yield:87394-55-6 100%
Reaction Conditions:
with trifluoroacetic acid in dichloromethane at 20; for 2.5 h;
Steps:
2.2A.2B
Step 2B; To a clear solution of tert-butyl 4-(3-chloropyridin-2-yl)piperazine-l- carboxylate in anhydrous dichloromethane (25 mL) was added TFA (25 mL) dropwise. The yellow solution was stirred at room temperature for 2.5 hour. Reaction was complete as determined by TLC. TFA was azeotropped with dichloroethane to give l-(3-chloropyridin-2- yl)piperazine in quantitative yield (1.265 g).IH NMR (400 MHz, DMSO-D6) δ ppm 3.19 - 3.32 (m, 4 H) 3.39 - 3.51 (m, 4 H) 7.10 (dd, J=7.83, 4.55 Hz, 2 H) 7.87 (dd, J=7.83, 1.52 Hz, 2 H) 8.27 (dd, J=4.80, 1.52 Hz, 2 H) 8.87 (s, I H).
References:
WO2007/92435,2007,A2 Location in patent:Page/Page column 92
110-85-0
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71-36-3
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96424-68-9
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