ChemicalBook CAS DataBase List 1,3-DIHYDROXYNAPHTHALENE

1,3-DIHYDROXYNAPHTHALENE synthesis

6synthesis methods

Product Name:1,3-DIHYDROXYNAPHTHALENE
CAS Number:132-86-5
Molecular formula:C10H8O2
Molecular Weight:160.17

1,3-Naphthalenediol is a derivative of naphthalene (N345600) and may have antibacterial activity against oral bacteria. It is obtained by decarboxylation of 1,3-dihydroxy-2-naphthoic acid.

135-19-3 Synthesis

135-19-3
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132-86-5
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Yield:-

Reaction Conditions:

with CYP₁₇₅A₁;dihydrogen peroxide in aq. phosphate buffer; pH=7.5 at 50; for 1 h;Kinetics;Enzymatic reaction;

Steps:

Enzymatic oxygenation of the substituted naphthalenes
General procedure: Oxygenation/oxidation of substituted naphthalene (see Table 1) by CYP175A1 was carried out by incubating 500 μL reaction mixture containing 10 μM CYP175A1, 500 μM substituted naphthalene (substrate) and 10 mM H₂O₂ in 50 mM KPi buffer (pH = 7.5) at 50 °C unless otherwise mentioned. The controls forthe reactions were carried out that contained all the reactants except CYP175A1 or except H₂O₂ in the assay mixture. Each reaction was allowed to proceed for 60 min unless otherwise stated.The reaction mixture was then extracted with 500 μL chloroform (containing 10% methanol) and the chloroform layer was collected,dried over anhydrous sodium sulfate, filtered through 0.2 μm syringe filter. The extracted reaction mixtures were then analyzed bydifferent mass spectrometry techniques.

References:

Banerjee, Shibdas;Goyal, Sandeep;Mazumdar, Shyamalava [Bioorganic Chemistry,2015,vol. 62,p. 94 - 105]

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91-20-3 Synthesis