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Chemical Properties Application Preparation
2-Naphthol structure
Chemical Name:
β-Naph;2-Naftol;Trimetin;NSC 2044;NSC 5737;c.i.37500;B-NAPHTOL;2-Naftolo;2-Naphtol;developera
Molecular Formula:
Formula Weight:
MOL File:

2-Naphthol Properties

Melting point:
120-122 °C(lit.)
Boiling point:
285-286 °C(lit.)
1,28 g/cm3
vapor density 
4.97 (vs air)
vapor pressure 
10 mm Hg ( 145.5 °C)
refractive index 
1.5762 (estimate)
Flash point:
153 °C
storage temp. 
Store below +30°C.
methanol: soluble1g/10 mL, clear, colorless to light yellow
9.51(at 25℃)
Powder, Crystals or Granules
PH Range
Non& uorescence (8.5) to blue & uorescence (9.5)
Water Solubility 
1 g/L (20 ºC)
226nm, 265nm, 275nm, 286nm, 320nm, 331nm
Stable. Combustible. Dust may form explosive mixture with air. Incompatible with strong oxidizing agents, phenol.
Major Application
Display device, semiconductors, photoimaging materials, inks, toner, chalk, security paper, molding materials, tin plating method, rubber, adhesive, leather, detergent, hair dyes, antimitotic drug, anticancer agent, antiinflammatory agent, treatment of acne vulgaris (pimples) and other dermal ailments (rashes, scratches, blemishes, hair loss), disorders
Indirect Additives used in Food Contact Substances
CAS DataBase Reference
135-19-3(CAS DataBase Reference)
EWG's Food Scores
NIST Chemistry Reference
EPA Substance Registry System
2-Naphthalenol (135-19-3)
  • Risk and Safety Statements
Signal word  Warning
Hazard statements  H302+H332-H400-H302-H332
Precautionary statements  P261-P264-P270-P301+P312a-P304+P340-P501a-P273
Hazard Codes  Xn,N
Risk Statements  20/22-50
Safety Statements  24/25-61
RIDADR  UN 3077 9/PG 3
WGK Germany  2
RTECS  QL2975000
Autoignition Temperature 430 °C
HazardClass  9
PackingGroup  III
HS Code  29071590
Toxicity LD50 orally in Rabbit: 1960 mg/kg LD50 dermal Rabbit > 10000 mg/kg
NFPA 704

2-Naphthol price More Price(17)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 130109 2-Naphthol 98% 135-19-3 250g $30.3 2021-03-22 Buy
Sigma-Aldrich 8.22290 2-Naphthol for synthesis 135-19-3 250 g $35.52 2021-03-22 Buy
Sigma-Aldrich 70450 2-Naphthol fluorescence indicator, ≥99.0% 135-19-3 100 g $41.7 2021-03-22 Buy
Sigma-Aldrich 8.22290 2-Naphthol for synthesis 135-19-3 1 kg $52.35 2021-03-22 Buy
Sigma-Aldrich 130109 2-Naphthol 98% 135-19-3 1kg $59.4 2021-03-22 Buy

2-Naphthol Chemical Properties,Uses,Production

Chemical Properties

White lustrous leaflets or white powder. Insoluble in water, soluble in ethanol, ether, chloroform, glycerol, and alkaline solutions.



(1) Sulfonation alkali melting method
Obtained by sulfonation of naphthalene and alkali melting. Sulfonation alkali melting 2-naphthol synthesis process is widely used in both domestic and foreign production, but it is with serious corrosion, high cost, large amount of waste water and high biological oxygen consumption. American Cyanamid Company developed 2-isopropyl-naphthalene method with naphthalene and propylene as the raw materials, which produces 2-naphthol and with byproduct acetone. This method is similar to Cumene process to produce phenol. The consumed amount of raw materials: 1170 kg/t refined naphthalene, 1080 kg/t sulfuric acid, 700 kg/t sodium hydroxide (caustic soda).
Details: Refined naphthalene was put into the sulfonation kettle and heated up to 140°C (melting). Sulfuric acid (sulfuric acid/refined naphthalene (mol/mol=1.8) was added within 20 minutes. The temperature was raised up to 160-164°C and kept for 2.5 h. The reaction was terminated when the content of 2-naphthalenesulfonic acid is above 66% and the total acidity is 25%-27%. The sulfonates were hydrolyzed for 1 h at 140-150°C inside a hydrolysis kettle. Following neutralization at 80-90°C with sodium nitrite solution was performed until the Congo red test paper was no more blue. Steam and air were used to remove SO2 gas. When the temperature was cooled down to 30-40°C, vacuum filtration was applied. After washing with salt water (10%) and following vacuum filtration, 2-naphthalenesulfonic acid sodium salt was obtained.
Sodium hydroxide was put into an alkali melting kettle and heated to 290°C (melting). At about 3 hours 2-naphthalenesulfonic acid sodium salt was added until the freebase content was 5%-6%. Afterwards, the temperature was kept at 320-330°C for 1 hour. The alkali melt was diluted with water and SO2 gas was passed at 70-80°C until phenolphthalein did not show any color. Addition of water to boil and wash, sodium sulfite was removed, dehydration and then under reduced pressure to distill the final product. The total yield is 73%-74%.
(2) 2-isopropyl-naphthalene method.
With naphthalene and ethylene as the raw materials to produce 2-naphthaol with byproduct acetone.
Details: Sulfuric acid was added into the melted naphthalene at 140℃ and the sulfonation was carried out at 162-164°C. The sulfonates were hydrolyzed, the free naphthalene was blown away and sodium sulfite was added to react and generate 2-naphthalenesulfonic acid sodium salt. This salt together with sodium hydroxide were alkali melted at 285-320°C and kept at 320-330°C for 1 hour. After the dilution of this alkali melt, acidification with SO2 gas was performed to obtain crude products. Followed washing, dehydration and distillation were carried out to obtain the final products.

Chemical Properties

white or off-white powder with a slight

Chemical Properties

2-Naphthol is a white, crystalline solid. Slight phenolic odor. Darkens in air and on exposure to light.


Has been used as antiseptic, anthelmintic and counter-irritant in alopecia.


anthelmintic, antiseptic


2-Naphthol is used in the manufacture of dyes, perfumes, and medicinal organics, and in the production of antioxidants for synthetic rubber.


products were made Naphthalen-2-ol, and sodium hydroxide melting, finally using hydrochloric acid or carbon dioxide exhalation.


ChEBI: A naphthol carrying a hydroxy group at position 2.

Synthesis Reference(s)

Journal of the American Chemical Society, 72, p. 4884, 1950 DOI: 10.1021/ja01167a009
Synthesis, p. 437, 1985 DOI: 10.1055/s-1985-31235


See α-naphthol

Health Hazard

Although the toxicity of 2-naphthol is of low order in test animals, ingestion of large amounts may result in nausea, vomiting, diarrhea, abdominal pain, convulsions, and hemolytic anemia. Death may result from respiratory failure. The oral LD50 value in rats is in the range 2000 mg/kg. 2-Naphthol is slightly more toxic than 1-naphthol [9015-3], the oral LD50 value of which is in the range 2500 mg/kg.
Skin contact can produce peeling of the skin and pigmentation.

Fire Hazard

Noncombustible solid.

Safety Profile

Poison by ingestion, inhalation, and subcutaneous routes. Mutation data reported. A skin and eye irritant. Combustible when exposed to heat or flame. To fight fire, use CO2, dry chemical. Incompatible with antipyrine, camphor, phenol, ferric salts, menthol, potassium permanganate and other oxidzing materials, urethane.

Potential Exposure

A potential danger to those involved in rubber antioxidant production, synthesis of dyes; leather processing; fungicides, pharmaceuticals, and perfumes. Used as an antioxidant for fats, oils; as an antiseptic; in insecticides.


UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN3077 Environmentally hazardous substances, solid, n.o.s., Hazard Class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required.

Properties and Applications

white crystalline, with phenol smell. Industrial goods for hoar chip or powder. Melting point 121 ~ 123 ℃, 285 ℃ ~ 286 boiling point, flash point 161 ℃. This product soluble in water, ethanol, ethyl ether, chloroform, glycerin and alkali solution, can the sublimation, with steam evaporate out; Long storage or light color in turn dark, can happen oxidation, reduction, nitrification and nitrosation reaction, and products, light and heat, halogenating role, etc.

Purification Methods

Crystallise 2-naphthol from aqueous 25% EtOH (charcoal), H2O, *benzene, toluene or CCl4. Alternatively, extract it repeatedly with small amounts of EtOH, followed by dissolution in a minimum volume of EtOH and precipitation with distilled water, then drying over P2O5 under vacuum. It has also been dissolved in aqueous NaOH and precipitated by adding acid (repeat several times), then precipitated from *benzene by addition of heptane. Final purification can be by zone melting or sublimation in vacuo. The 4-nitrobenzoate has m 104o (from EtOH). [Bardez et al. J Phys Chem 89 5031 1985, Kikuchi et al. J Phys Chem 91 574 1987, Beilstein 6 IV 4253.]


Dust or powder may form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, iron salts; 2,3-dimethyl-1- phenyl-3-pyrazolin-5-one (antipyrine); camphor, phenol, menthol, urethane.

Waste Disposal

Mix with flammable solvent and atomize into an incinerator.

2-Naphthol Preparation Products And Raw materials

Raw materials

Preparation Products

2-Naphthol Suppliers

Global( 510)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hubei xin bonus chemical co. LTD
027-59338440 CHINA 23035 58
13806087780 +86 13806087780 CHINA 17384 58
Henan DaKen Chemical CO.,LTD.
+86-371-66670886 China 20890 58
Dalian Richfortune Chemicals Co., Ltd
86-411-84821380 China 300 57
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 22607 55
Hangzhou FandaChem Co.,Ltd.
+86-571-56059825 CHINA 8910 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418697 China 3000 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038 CHINA 3623 58
career henan chemical co
+86-371-86658258 CHINA 29954 58
13867897135 CHINA 925 58

View Lastest Price from 2-Naphthol manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-12-07 2-Naphthol
US $1.00 / g 1g 99 20 tons Shanghai Longyu Biotechnology Co., Ltd.
2021-12-01 2-Naphthol
US $11.00 / ASSAYS 1ASSAYS 99% 10000kg Hebei Crovell Biotech Co Ltd
2021-11-08 2-Naphthol Purity 99%
US $10.00 / KG 1KG 99.9% 100MT/Month Wuhan wingroup Pharmaceutical Co., Ltd

2-Naphthol Spectrum

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