1,3-Dioxane, 5,5-bis(broMoMethyl)-2-phenyl- synthesis
- Product Name:1,3-Dioxane, 5,5-bis(broMoMethyl)-2-phenyl-
- CAS Number:3733-29-7
- Molecular formula:C12H14Br2O2
- Molecular Weight:350.05
3296-90-0
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3733-29-7
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$65.00/500mg
Yield:3733-29-7 95%
Reaction Conditions:
with toluene-4-sulfonic acid in toluene at 120; for 4 h;
Steps:
36.A Step A: 5,5-bis(bromomethyl)-2-phenyl-1,3-dioxane (Compound 36.1)
Dissolve 2,2-bis(bromomethyl)propane-1,3-diol (10g, 38.18mmol) in 140mL of toluene,Add benzaldehyde (4.25g, 40.09mmol)And p-toluenesulfonic acid (657mg, 3.82mmol), the reaction solution was raised to 120 degrees, and reacted for 4 hours.The reaction solution was cooled to room temperature and washed 3 times with saturated sodium bicarbonate solution (40 mL),Wash with saturated brine (30mL) once, dry with anhydrous sodium sulfate, filter, spin dry,The residue was recrystallized from methanol at room temperature to obtain the product 36.1 (12.7 g, yield: 95%, white solid).
References:
CN111217834,2020,A Location in patent:Paragraph 0645-0651
115-77-5
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3733-29-7
32 suppliers
$65.00/500mg