1-(3-NITRO-4-PIPERIDINOPHENYL)-1-ETHANONE synthesis

5synthesis methods

Product Name:1-(3-NITRO-4-PIPERIDINOPHENYL)-1-ETHANONE
CAS Number:30877-80-6
Molecular formula:C13H16N2O3
Molecular Weight:248.28

110-89-4
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$15.96/100ML

400-93-1
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$14.00/5g

1-(3-NITRO-4-PIPERIDINOPHENYL)-1-ETHANONE

30877-80-6
24 suppliers
$28.60/5MG

Yield:30877-80-6 85%

Reaction Conditions:

with triethylamine in acetonitrile at 20;

Steps:

300.1

Step 1: 1-(3-nitro-4-(piperidin-1-yl)phenyl)ethanone: Piperidine (539 μl, 5.46 mmol) was added to a solution of 1-(4-fluoro-3-nitrophenyl)ethanone (1 g, 5.46 mmol) and Et₃N (2.28 ml, 16.4 mmol) in MeCN (10 ml) and the resultant solution was stirred at RT overnight. The reaction mixture was concentrated in vacuo to afford the title compound (1.2 g, 4.64 mmol, 85% yield, 96% purity) as a red oil. UPLC-MS (Method 1) m/z 249.3 (M+H)⁺ at 1.48 min.

References:

WO2020/104822,2020,A1 Location in patent:Page/Page column 94; 278

110-89-4
3 suppliers
$15.96/100ML