1-(3-NITRO-4-PIPERIDINOPHENYL)-1-ETHANONE synthesis
- Product Name:1-(3-NITRO-4-PIPERIDINOPHENYL)-1-ETHANONE
- CAS Number:30877-80-6
- Molecular formula:C13H16N2O3
- Molecular Weight:248.28
110-89-4
0 suppliers
$15.96/100ML
400-93-1
227 suppliers
$14.00/5g
30877-80-6
26 suppliers
$28.60/5MG
Yield:30877-80-6 85%
Reaction Conditions:
with triethylamine in acetonitrile at 20;
Steps:
300.1
Step 1: 1-(3-nitro-4-(piperidin-1-yl)phenyl)ethanone: Piperidine (539 μl, 5.46 mmol) was added to a solution of 1-(4-fluoro-3-nitrophenyl)ethanone (1 g, 5.46 mmol) and Et3N (2.28 ml, 16.4 mmol) in MeCN (10 ml) and the resultant solution was stirred at RT overnight. The reaction mixture was concentrated in vacuo to afford the title compound (1.2 g, 4.64 mmol, 85% yield, 96% purity) as a red oil. UPLC-MS (Method 1) m/z 249.3 (M+H)+ at 1.48 min.
References:
WO2020/104822,2020,A1 Location in patent:Page/Page column 94; 278
110-89-4
0 suppliers
$15.96/100ML
5465-65-6
224 suppliers
$16.00/5G
30877-80-6
26 suppliers
$28.60/5MG
99-91-2
433 suppliers
$10.00/25g
30877-80-6
26 suppliers
$28.60/5MG
5465-65-6
224 suppliers
$16.00/5G
30877-80-6
26 suppliers
$28.60/5MG
110-89-4
0 suppliers
$15.96/100ML
18640-58-9
203 suppliers
$5.00/250mg
30877-80-6
26 suppliers
$28.60/5MG