1-(3-NITRO-4-PIPERIDINOPHENYL)-1-ETHANONE synthesis
- Product Name:1-(3-NITRO-4-PIPERIDINOPHENYL)-1-ETHANONE
- CAS Number:30877-80-6
- Molecular formula:C13H16N2O3
- Molecular Weight:248.28
110-89-4
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30877-80-6
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Yield:30877-80-6 85%
Reaction Conditions:
with triethylamine in acetonitrile at 20;
Steps:
300.1
Step 1: 1-(3-nitro-4-(piperidin-1-yl)phenyl)ethanone: Piperidine (539 μl, 5.46 mmol) was added to a solution of 1-(4-fluoro-3-nitrophenyl)ethanone (1 g, 5.46 mmol) and Et3N (2.28 ml, 16.4 mmol) in MeCN (10 ml) and the resultant solution was stirred at RT overnight. The reaction mixture was concentrated in vacuo to afford the title compound (1.2 g, 4.64 mmol, 85% yield, 96% purity) as a red oil. UPLC-MS (Method 1) m/z 249.3 (M+H)+ at 1.48 min.
References:
WO2020/104822,2020,A1 Location in patent:Page/Page column 94; 278
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30877-80-6
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5465-65-6
216 suppliers
$16.00/5G
30877-80-6
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$28.60/5MG
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30877-80-6
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