1-(4-BROMOBUTOXY)-2,4-DICHLOROBENZENE synthesis
- Product Name:1-(4-BROMOBUTOXY)-2,4-DICHLOROBENZENE
- CAS Number:37395-50-9
- Molecular formula:C10H11BrCl2O
- Molecular Weight:298
Yield:37395-50-9 74.5%
Reaction Conditions:
with potassium carbonate in acetonitrile at 80; for 8 h;
Steps:
10 1-bromo-4-(2',4'-dichlorophenoxy) butane
2,4-dichlorophenol (8.2g, 0 . 05mol), 1,4-dibromo-butane (52g, 0.25mol), potassium carbonate (10g, 0.075mol) underwaterly to 100 ml in acetonitrile, 80 °C reaction under 8 hours. Monitoring phenol exertion end is TLC, cessation of the reaction, is placed to the room temperature, oil filtration to solid, the filtrate concentrated under reduced pressure, by adding 100 ml of chloroform, for chloroform level 0.2N two washing the sodium hydroxide aqueous solution (100 ml * 2), drying with anhydrous magnesium sulfate. Vacuum distillation, 0.65mbar pressure, taking 129-130 °C fraction, get colorless oily 11.1g, yield of 74.5%.
References:
CN103664972,2016,B Location in patent:Paragraph 0202; 0203; 0204
