1-(4-CHLORO-2-HYDROXYPHENYL)PROPAN-1-ONE synthesis
- Product Name:1-(4-CHLORO-2-HYDROXYPHENYL)PROPAN-1-ONE
- CAS Number:1127-97-5
- Molecular formula:C9H9ClO2
- Molecular Weight:184.62
without solvent at 100° for 2 h (92%), at 140° for 2 h (89%), ? at 140–150° for 3 h, at 130° for 2 h (77%), at 165° for 1 h (72%), at 50° for 3 h (55%) or at 30–40° (53%)
n nitrobenzene at 25° for 6 h (87%)
Preparation by Fries rearrangement of m-chlorophenyl propionate with titanium tetrachloride at 100° for 2 h (75%)
Also obtained by Friedel–Crafts reaction of propionyl chloride with m-chlorophenol in the presence of aluminium chloride
Also obtained by isomerization of 2-chloro-4-hydroxypropiophenone on heating with aluminium chloride between 165° and 200° (30–70%).
6603-24-3
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1127-97-5
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Yield:1127-97-5 89.2%
Reaction Conditions:
with aluminium trichloride at 140; for 2 h;
References:
Shiozawa;Narita;Izumi;Kurashige;Sakitama;Ishikawa [European Journal of Medicinal Chemistry,1995,vol. 30,# 1,p. 85 - 94]
36871-55-3
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1127-97-5
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$200.00/50mg
6285-05-8
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1127-97-5
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205320-02-1
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1127-97-5
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57479-70-6
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$10.00/1g
1127-97-5
26 suppliers
$200.00/50mg