4'-Chloropropiophenone synthesis
- Product Name:4'-Chloropropiophenone
- CAS Number:6285-05-8
- Molecular formula:C9H9ClO
- Molecular Weight:168.62
Yield:6285-05-8 96.5%
Reaction Conditions:
with Aluminum Chloride in dichloromethane at 10 - 25; for 2 h;Solvent;Temperature;Reagent/catalyst;
Steps:
1 Example 1
Chlorobenzene (0.1 mol), with stirring,Dichloromethane (100 mL) and anhydrous aluminum trichloride (0.12 mol)Add to the reaction vessel.Temperature 10 ° C,Propionyl chloride (0.11 mol) was added dropwise slowly.After the addition is completed, the temperature is raised to 25 ° C for 2 hr.TLC detects chlorobenzene without residue,Stop the reaction,Filtering,Collecting mother liquor,The mother liquor was successively treated with 5% citric acid (100 ml).Wash with saturated sodium bicarbonate (100 ml) and saturated brine.Dry over anhydrous sodium sulfate,Then concentrate the mother liquor,Obtained a white solid,Collecting solids,Melting point 35~37 °C,The yield is 96.5 % based on chlorobenzene.The purity of HPLC was 98.9%.This solid is p-chloropropiophenone.
References:
CN108752229,2018,A Location in patent:Paragraph 0018; 0022; 0026; 0030; 0034
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