1-(4-CHLOROBENZYL)-1H-IMIDAZOLE synthesis
- Product Name:1-(4-CHLOROBENZYL)-1H-IMIDAZOLE
- CAS Number:42032-27-9
- Molecular formula:C10H9ClN2
- Molecular Weight:192.64
Yield:42032-27-9 93%
Reaction Conditions:
with potassium carbonate in acetonitrile;Reflux;
Steps:
5.2. General procedure 1
General procedure: Compounds 1-18 were synthesized using the following generalprocedure reported by Salvio et al. [41]. A mixture of potassium carbonate(2.0 g, 14.4 mmol), imidazole derivatives 27-28 (32.9 mmol)and compounds 29-37 (4.7 mmol) in dry acetonitrile (50 ml) was heatedunder reflux and the progress of the reaction was monitored byTLC. Then the solvent was evaporated under the vacuum and the residuewas dissolved in DCM (100 ml) *. The organic layer was washedwith saturated sodium bicarbonate aqueous solution (2×50 ml),passed through diatomaceous earth, dried over sodium sulfate, evaporatedunder the vacuum, and purified by flash column chromatography(ethyl acetate-hexane 0-100%)** to give the products 1-18.*Note 1: Ethyl acetate (200 ml) was used for compounds 17 and 18.**Note 2: Compounds 17 and 18 (ethyl acetate-methanol 0-100%).
References:
Khalili Arjomandi, Omid;Kavoosi, Mahboubeh;Adibi, Hadi [Bioorganic Chemistry,2019,vol. 92,art. no. 103277]
104-83-6
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