1-(4-CHLOROMETHYL-PHENYL)-PYRROLIDIN-2-ONE synthesis
- Product Name:1-(4-CHLOROMETHYL-PHENYL)-PYRROLIDIN-2-ONE
- CAS Number:36152-29-1
- Molecular formula:C11H12ClNO
- Molecular Weight:209.67
![1-[4-(hydroxymethyl)phenyl]pyrrolidin-2-one](/CAS/20200331/GIF/1204311-22-7.gif)
1204311-22-7
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36152-29-1
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Yield:36152-29-1 92%
Reaction Conditions:
with thionyl chloride in dichloromethane; for 0.5 h;
Steps:
105
To a solution of 1 -(4-(hydroxymethyl)phenyl)pyrrolidin-2-one (208 mg, 1.1 mmol, 1.0 eq) in dry DCM (10 mL) was added thionyl chloride (0.16 mL, 2.2 mmol, 2.0 eq). The reaction mixture was stirred for 30 min, concentrated, and the residue was purified via flash chromatography (PE/DCM/EA = 1/1/1) to afford l-(4- (chloromethyl)phenyl)pyrrolidin-2-one as a white solid (210 mg, 92%). LRMS (M+H+) m/z calculated 444.2, found 444.2.
References:
WO2015/103317,2015,A1 Location in patent:Page/Page column 192
221381-89-1
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36152-29-1
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$64.00/250mg
619-42-1
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36152-29-1
19 suppliers
$64.00/250mg