1-(4-fluoro-2-nitrophenyl)propan-2-one synthesis
- Product Name:1-(4-fluoro-2-nitrophenyl)propan-2-one
- CAS Number:39616-99-4
- Molecular formula:C9H8FNO3
- Molecular Weight:197.16
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Yield:39616-99-4 95.5%
Reaction Conditions:
with acetic acid at 112; for 3 h;Reagent/catalyst;Temperature;Solvent;
Steps:
2
Add 400g of acetic acid to the 1000ml reaction bottle.82.4 g of 3-(4-fluoro-2-nitrophenyl)-4-hydroxy-3-penten-2-one,20g resin catalyst D002,Stir and gradually heat to 112 ° C,When the reaction was carried out for 3 h and the content of 3-(4-fluoro-2-nitrophenyl)-4-hydroxy-3-penten-2-one was <0.2% by liquid chromatography,The reaction is over.The reaction solution is filtered hot,And washing the catalyst with 40 g of acetic acid,The filtrate is stripped of about half of the solvent and cooled to 25-30 ° C.Precipitate a large amount of solids, filter,After the filter cake was dried, 66.9 g of 3-(4-fluoro-2-nitrophenyl)acetone was obtained.The content was 97%, the yield was 95.5%, the filtrate was desolvated, the solvent and the catalyst were directly applied to the next batch, and the residue was 12 g.In this method, 100 g of the product produced 18 g of organic residue, and 1 g of spent catalyst (the catalyst was used according to the use of 30 wastes), and the reaction of this step did not generate exhaust gas and waste water.
References:
CN108203385,2018,A Location in patent:Paragraph 0021; 0023; 0024; 0026; 0028; 0030
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