1-(4-Methoxy-benzyl)-1H-pyrazole-4-carbaldehyde synthesis
- Product Name:1-(4-Methoxy-benzyl)-1H-pyrazole-4-carbaldehyde
- CAS Number:153687-35-5
- Molecular formula:C12H12N2O2
- Molecular Weight:216.24
824-94-2
35344-95-7
153687-35-5
Potassium carbonate (287 mg, 2.08 mmol) was added to a mixture of 1H-pyrazole-4-carbaldehyde (100 mg, 1.04 mmol) and 1-(chloromethyl)-4-methoxybenzene (162 mg, 1.04 mmol) in acetonitrile (6 mL). The reaction mixture was heated to reflux and stirred for 1 hour. Upon completion of the reaction, the mixture was poured into water (20 mL) and extracted with ethyl acetate (3 x 20 mL). The organic layers were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to give 1-(4-methoxybenzyl)-1H-pyrazole-4-carbaldehyde (220 mg, 93.3% yield) as a colorless oil.
824-94-2
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$24.19/5G
35344-95-7
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$32.00/1g
153687-35-5
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$60.00/100mg
Yield:153687-35-5 93.3%
Reaction Conditions:
with potassium carbonate in acetonitrile; for 1 h;Reflux;
Steps:
32.1 Synthesis of 1-(4-methoxybenzyl)-1H-pyrazole-4-carbaldehyde
To a mixture of 1H-pyrazole-4-carbaldehyde (100 mg, 1.04 mmol) and 1- (chloromethyl)-4-methoxybenzene (162 mg, 1.04 mmol) in CH3CN (6 mL) was added potassium carbonate (287 mg, 2.08 mmol), the resulting mixture was stirred at reflux for 1 h. The mixture was poured into water (20 mL) and extracted with EtOAc (3×20 mL). The organic layer was dried over Na2SO4and concentrated to give 1-(4-methoxybenzyl)- 1H-pyrazole-4-carbaldehyde (220 mg, 93.3 %) as a colorless oil
References:
KR2017/45749,2017,A Location in patent:Paragraph 1087; 1090-1092
145162-51-2
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153687-35-5
38 suppliers
$60.00/100mg
824-94-2
444 suppliers
$24.19/5G
153687-35-5
38 suppliers
$60.00/100mg