1-(4-METHYLBENZYL)PIPERAZINE synthesis
- Product Name:1-(4-METHYLBENZYL)PIPERAZINE
- CAS Number:435345-17-8
- Molecular formula:C12H18N2
- Molecular Weight:190.28
142-64-3
178 suppliers
$11.00/25g
104-82-5
347 suppliers
$10.00/5mL
435345-17-8
21 suppliers
$110.00/50mg
Yield:435345-17-8 72%
Reaction Conditions:
Stage #1: piperazine dihydrochloride in methanol;Heating;
Stage #2: 4-Methylbenzyl chloridewith copper(II) ions supported on commercial polymeric resinMicrowave irradiation;Reflux;
Steps:
Batch microwave assisted experiments (B)
General procedure: follow classic flask procedures closely. Reaction mixtureswere prepared in the very same way and a relevant supported catalyst was added in amount of0.05: 1 mol. with respect to a corresponding reagent. Subsequently, the flask was put into the microwaveoven and equipped with a glass tube adaptor and a reux condenser. After this, MW irradiation wasemployed instead of regular heating (reflux). Microwave oven power was always set to a minimalenergy (10% of a maximal power, i.e., 80 W) and then applied using a pulse mode (typically 3 sec. of aset power then pause for 4 sec.) to keep the reaction mixture in the flask only slightly boiling.
References:
?ev?ík, Richard;?imbera, Jan;Havránková, Eva;Něme?ková, Dana;Pazdera, Pavel [Molecules,2020,vol. 25,# 9]
111752-26-2
57 suppliers
$45.00/25mg
435345-17-8
21 suppliers
$110.00/50mg