1-(4-Trifluoromethyl-thiazol-2-yl)-piperazine synthesis
- Product Name:1-(4-Trifluoromethyl-thiazol-2-yl)-piperazine
- CAS Number:107507-53-9
- Molecular formula:C8H10F3N3S
- Molecular Weight:237.25
668484-48-8
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Yield:-
Reaction Conditions:
with trifluoroacetic acid in dichloromethane at 20; for 2 h;
Steps:
53.2
The intermediate from step 1 (0.5 g) was stirred in a mixture of TFA (10 mL) and CH2Cl2 (40 mL) at room temperature for 2 hours, then concentrated. To remove remaining TFA, the residue was re-dissolved in CH2Cl2 (50 mL) and concentrated again to give 0.3 g of intermediate 1-(4-Trifluoromethyl-thiazol-2-yl)-piperazine as a light yellow oil.
References:
US2005/234046,2005,A1 Location in patent:Page/Page column 61
110-85-0
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228119-52-6
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