1-(5-bromo-3-pyridinyl)-1-propanone synthesis
- Product Name:1-(5-bromo-3-pyridinyl)-1-propanone
- CAS Number:341555-43-9
- Molecular formula:C8H8BrNO
- Molecular Weight:214.06
2386-64-3
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Yield:341555-43-9 88%
Reaction Conditions:
in tetrahydrofuran at 10; for 4 h;
Steps:
1.1 1. Synthesis of (5-bromopyridin-3-yl) ethyl ketone
20.8 g of N-methyl-N-methoxy-5-bromo-nicotinamide was dissolved in 200 ml of tetrahydrofuran, cooled to 10 degrees, and 45 ml of a 2 M solution of ethylmagnesium chloride in tetrahydrofuran was added.After the reaction was continued for 4 hours, it was warmed to room temperature and quenched with water.It was extracted twice with ethyl acetate and the organic phase was desolvated. Distillation under reduced pressure gave 16 g of a pale yellow solid with a yield of 88%.
References:
CN107954927,2018,A Location in patent:Paragraph 0016
39620-02-5
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811-49-4
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360 suppliers
$12.00/5ml
183608-47-1
45 suppliers
$110.00/500mg
341555-43-9
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20826-04-4
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