1-(5-fluoro-2-nitrophenyl)propan-2-one synthesis
- Product Name:1-(5-fluoro-2-nitrophenyl)propan-2-one
- CAS Number:1266659-06-6
- Molecular formula:C9H8FNO3
- Molecular Weight:197.16
123-42-2
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1266659-06-6
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Yield:-
Reaction Conditions:
with palladium diacetate;caesium carbonate;triphenylphosphine in toluene at 120; for 7 h;Inert atmosphere;
Steps:
7.1
palladium acetate (0.025mmol, 6 mg), triphenylphosphine (0.10mmol, 26 mg), cesium carbonate (0.75mmol, 244 mg) and 1g (0.5mmol, 110 mg) is put into the 25 ml reaction tube, sufficient vacuum, nitrogen (three times). Under the protection of nitrogen injected into the injector 2a diacetonealcohol (3.0mmol, 348 mg), toluene 3 ml. In the 120 °C pot oil bath stirring 7h, after cooling to room temperature the temperature of the reaction system by adding 20 ml water, add 25 ml ethyl acetate extraction, grass-roots takes has saturated salt water for washing, for Na2 SO4 Drying, then adding a small amount of silica gel turns on lathe the main column chromatography.
References:
CN106631968,2017,A Location in patent:Paragraph 0069-0073
1266659-05-5
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1266659-06-6
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$972.00/5g
446-35-5
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1266659-06-6
18 suppliers
$972.00/5g