ChemicalBook CAS DataBase List 1,7-DIMETHYLXANTHINE

1,7-DIMETHYLXANTHINE synthesis

7synthesis methods

Product Name:1,7-DIMETHYLXANTHINE
CAS Number:611-59-6
Molecular formula:C7H8N4O2
Molecular Weight:180.16

1H-Purine-2,6-dione,3,7-dihydro-1,7-dimethyl-3-(phenylmethyl)-

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Yield:611-59-6 90%

Reaction Conditions:

with boron tribromide in toluene at 80; for 2 h;Reagent/catalyst;Temperature;Solvent;

Steps:

2; 3; 6; 7; 8; 9; 10

3-Benzyl-1,7-dimethylxanthine (10 g, 37.2 mmol) was suspended in toluene (150 mL).Boron tribromide (18.6 g, 74.4 mmol) was added. The temperature was raised to 80 ° C for 2 hours.TLC showed the reaction was complete. Cool down to 0-10 ° C,Water (150 mL) was added dropwise and stirred for 2 hours.After filtration, it is beaten with ethanol to obtain a white solid.1,7-dimethylxanthine 6.0g,Yield 90%,The purity is 98%.

References:

CN109796453,2019,A Location in patent:Paragraph 0045; 0048; 0049; 0052; 0061; 0064; 0065; 0068

55782-76-8 Synthesis