1-acetyl-6-bromo-1,2,3,4-tetrahydroquinoline synthesis
- Product Name:1-acetyl-6-bromo-1,2,3,4-tetrahydroquinoline
- CAS Number:22190-40-5
- Molecular formula:C11H12BrNO
- Molecular Weight:254.12
4169-19-1
60 suppliers
$60.00/500mg
22190-40-5
44 suppliers
$36.00/250mg
Yield:22190-40-5 96%
Reaction Conditions:
with N-Bromosuccinimide in DMF (N,N-dimethyl-formamide) at 20; for 3 h;
Steps:
Crude 1- (3, 4-dihydro-2H-quinolin-1-yl)-ethanone was dissolved in DMF (60 mL), and N-bromo succinimide (100 mmol) was added portion wise. Stirred at room temperature for 3h, then the reaction mixture was poured into water (150 mL) and extracted with ethyl acetate. The organic phase was washed with NH4C1 (sat. ), dried over MgS04, filtered and evaporated. Yield: 96% 1H NMR (D6-DMSO) : 1.85 (m, 2H); 2.16 (s, 3H); 2.70 (m, 2H); 3.66 (m, 2H); 7.25- 7.60 (3H).
References:
WO2005/39572,2005,A1 Location in patent:Page/Page column 31
22190-35-8
156 suppliers
$25.00/250mg
75-36-5
589 suppliers
$17.92/100G
22190-40-5
44 suppliers
$36.00/250mg
5263-87-6
317 suppliers
$15.00/5g
22190-40-5
44 suppliers
$36.00/250mg
635-46-1
365 suppliers
$5.00/10g
22190-40-5
44 suppliers
$36.00/250mg