
1-acetyl-6-bromo-1,2,3,4-tetrahydroquinoline synthesis
- Product Name:1-acetyl-6-bromo-1,2,3,4-tetrahydroquinoline
- CAS Number:22190-40-5
- Molecular formula:C11H12BrNO
- Molecular Weight:254.12

4169-19-1
61 suppliers
$60.00/500mg

22190-40-5
44 suppliers
$36.00/250mg
Yield:22190-40-5 96%
Reaction Conditions:
with N-Bromosuccinimide in DMF (N,N-dimethyl-formamide) at 20; for 3 h;
Steps:
Crude 1- (3, 4-dihydro-2H-quinolin-1-yl)-ethanone was dissolved in DMF (60 mL), and N-bromo succinimide (100 mmol) was added portion wise. Stirred at room temperature for 3h, then the reaction mixture was poured into water (150 mL) and extracted with ethyl acetate. The organic phase was washed with NH4C1 (sat. ), dried over MgS04, filtered and evaporated. Yield: 96% 1H NMR (D6-DMSO) : 1.85 (m, 2H); 2.16 (s, 3H); 2.70 (m, 2H); 3.66 (m, 2H); 7.25- 7.60 (3H).
References:
WO2005/39572,2005,A1 Location in patent:Page/Page column 31

22190-35-8
156 suppliers
$25.00/250mg

75-36-5
589 suppliers
$17.92/100G

22190-40-5
44 suppliers
$36.00/250mg

5263-87-6
316 suppliers
$15.00/5g

22190-40-5
44 suppliers
$36.00/250mg

635-46-1
366 suppliers
$5.00/10g

22190-40-5
44 suppliers
$36.00/250mg