1-ALLYLOXY-3-METHYLAMINO-PROPAN-2-OL synthesis
- Product Name:1-ALLYLOXY-3-METHYLAMINO-PROPAN-2-OL
- CAS Number:40987-35-7
- Molecular formula:C7H15NO2
- Molecular Weight:145.2
106-92-3
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40987-35-7
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$45.00/10mg
Yield:40987-35-7 81%
Reaction Conditions:
in methanol;water at 25;
Steps:
9
Synthesis Example 940 weight% methylamine in water (233 g, 3.0 mol) and methanol (35 mL) were placed in a 500 mL 4-necked flask, and a mechanical stirrer, dropping funnel, reflux condenser, and glass stopper were attached. A solution of allyl glycidyl ether (34.2 g, 0.3 mol)/methanol (35 mL) was added dropwise into the flask over the course of approximately 5 hours while maintaining the 4- necked flask at a temperature of approximately 25°C using a circulator. Completion of the reaction was confirmed using GC.After the reaction was complete, the reaction solution was concentrated in an evaporator. The liquid obtained was purified using distillation under reduced pressure (full vac, 76°C). The yield was 35.3 g (81% yield) and the GC purity was 99.2%.
References:
WO2011/116206,2011,A1 Location in patent:Page/Page column 42
106-92-3
290 suppliers
$14.00/5mL
40987-35-7
14 suppliers
$45.00/10mg