(1-amino-3-phenylpropan-2-yl)(methyl)amine synthesis

2synthesis methods

Product Name:(1-amino-3-phenylpropan-2-yl)(methyl)amine
CAS Number:128899-93-4
Molecular formula:C10H16N2
Molecular Weight:164.25

Carbamic acid, [2-amino-2-oxo-1-(phenylmethyl)ethyl]-, ethyl ester, (S)- (9CI)

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(1-amino-3-phenylpropan-2-yl)(methyl)amine

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Yield:-

Reaction Conditions:

with LiAlH₄;sodium carbonate in tetrahydrofuran;water;

Steps:

17.25.3 (3)

(3) 1-Amino-(S)-2-N-Methylamino-3-Phenylpropane There was added 10 mmoles (2.36 grams) of N-ethyloxycarbonyl-(L)-phenylalanineamide (produced from (L)-phenylalanineamide and ethyl chloroformate in the presence of Na₂ CO₃ in an ice bath) in small portions to an ice cooled suspension of 90 mmoles (3.41 grams) of LiAlH₄ in 110 ml of tetrahydrofuran. The mixture was heated at reflux for 24 hours. Hydrolysis was carried out under ice ooling with 360 mmoles (6.50 ml) of water. Further working up was analogous to (a). The product was distilled in a high vacuum (10^-4 Torr) at 75° C. air bath temperature. Colorless liquid, M.P. of the hydrochloride 160° C.

References:

US4704464,1987,A

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References