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Ethyl chloroformate

Ethyl chloroformate
Ethyl chloroformate structure
Chemical Name:
Ethyl chloroformate
ECF;tl423;TL 423;cathylchloride;Cathyl chloride;Choroformicester;AKOS BBS-00004329;Ethylchlorformiat;etilcloroformiato;ethyl chlorofomate
Molecular Formula:
Formula Weight:
MOL File:

Ethyl chloroformate Properties

Melting point:
-81 °C
Boiling point:
94 °C
1.139 g/mL at 20 °C
vapor density 
3.74 (vs air)
vapor pressure 
3.42 psi ( 20 °C)
refractive index 
n20/D 1.395(lit.)
Flash point:
57 °F
storage temp. 
White to off-white
Irritating; sharp, like hydrochloric acid.
Water Solubility 
Moisture Sensitive
CAS DataBase Reference
541-41-3(CAS DataBase Reference)
NIST Chemistry Reference
Carbonochloridic acid, ethyl ester(541-41-3)
EPA Substance Registry System
Carbonochloridic acid, ethyl ester(541-41-3)
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
  • NFPA
Hazard Codes  F,T+,N
Risk Statements  11-22-26-34-50
Safety Statements  9-16-26-28-33-36/37/39-45-61
RIDADR  UN 1182 6.1/PG 1
WGK Germany  1
RTECS  LQ6125000
Autoignition Temperature 842 °F
HazardClass  6.1
PackingGroup  I
HS Code  29151300
Hazardous Substances Data 541-41-3(Hazardous Substances Data)
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H314 Causes severe skin burns and eye damage Skin corrosion/irritation Category 1A, B, C Danger P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
H330 Fatal if inhaled Acute toxicity,inhalation Category 1, 2 Danger P260, P271, P284, P304+P340, P310,P320, P403+P233, P405, P501
Precautionary statements:
P320 Specific treatment is urgent (see … on this label).
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

NFPA 704

Diamond Hazard Value Description
4 1
Health   4 Very short exposure could cause death or major residual injury (e.g. hydrogen cyanide, phosgene, methyl isocyanate, hydrofluoric acid)
Flammability   3 Liquids and solids (including finely divided suspended solids) that can be ignited under almost all ambient temperature conditions . Liquids having a flash point below 22.8 °C (73 °F) and having a boiling point at or above 37.8 °C (100 °F) or having a flash point between 22.8 and 37.8 °C (73 and 100 °F). (e.g. gasoline, acetone)
Instability   1 Normally stable, but can become unstable at elevated temperatures and pressures (e.g. propene)

(NFPA, 2010)

Ethyl chloroformate price

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Ethyl chloroformate Chemical Properties,Uses,Production

Chemical Properties

Colorless to yellow liquid

Chemical Properties

A colorless to light yellow liquid. Sharp, pungent odor, similar to HCl.


Cathyl Chloride is used in the preparation of new inhibitors for β-homocysteine S-methyltransferase. Also used in the synthesis of a hexosaminidase inhibitor.

General Description

A colorless liquid with a pungent odor. Flash point 66°F. Very toxic by inhalation. Corrosive to metals and tissue. Vapors are heavier than air. Prolonged exposure to low concentrations or short exposure to high concentrations may have adverse health effects from inhalation.

Air & Water Reactions

Highly flammable. Emits fumes containing HCl on contact with moist air. Decomposes exothermically but slowly in water.

Reactivity Profile

Ethyl chloroformate decomposes slowly in water to form ethanol, HCl, and CO2 Attacks many metals especially in humid atmosphere [Handling Chemicals Safely 1980. p. 476]. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].


Flammable, dangerous fire risk. Strong irritant to eyes and skin.

Health Hazard

Inhalation causes mucous membrane irritation, coughing, and sneezing. Vapor causes severe lachrymation; liquid causes acid-type burns of eyes and skin, like those of hydrochloric acid. Ingestion causes severe burns of mouth and stomach.

Fire Hazard

Special Hazards of Combustion Products: Toxic chlorine and phosgene gases may be formed in fires.

Fire Hazard

Flash Point (°F): 82 ℃; 61 ℃; Flammable Limits in Air (%): Data not available; Fire Extinguishing Agents: Water, dry chemical, carbon dioxide; Fire Extinguishing Agents Not To Be Used: Not pertinent; Special Hazards of Combustion Products: Toxic chlorine and phosgene gas may be formed in fires; Behavior in Fire: Not pertinent; Ignition Temperature (°F): 932; Electrical Hazard: Data not available; Burning Rate: No data.

Chemical Reactivity

Reactivity with Water: Slow reaction with water, evolving hydrogen chloride (hydrochloric acid); Reactivity with Common Materials: Slow evolution of hydrogen chloride from surface moisture reaction can cause slow corrosion; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Flush with water, rinse with sodium bicarbonate or lime solution; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.

Safety Profile

Poison by ingestion, inhalation, and intraperitoneal routes. Moderately toxic by skin contact. Corrosive. An eye, skin, and mucous membrane irritant. A very dangerous fire hazard when exposed to heat or flame; can react vigorously with oxidzing materials. Reacts with water or steam to produce toxic and corrosive fumes. To fight fire, use CO2, dry chemical. When heated to decomposition it emits highly toxic fumes of Cl-.

Potential Exposure

Heavily used in industry for various processes; in ore processing, photography, making other chemicals including amines, carbamates, isocyanates; polymers, diethyl carbonate; nitriles, etc.

First aid

Inhalation: remove to fresh air; use artificial respiration if breathing has stopped; call a doctor; keep victim quiet and administer oxygen if needed. Eyes: flush with water for at least 15 min.; see a doctor. Skin: wash liberally with water for at least 15 min., then apply dilute solution of sodium bicarbonate or commercially prepared neutralizer. Ingestion: do NOT induce vomiting; give large amount of water; get medical attention


UN1182 Ethyl chloroformate, Hazard class: 6.1; Labels: 6.1-Poison Inhalation Hazard, 3-Flammable liquid, 8-Corrosive material Inhalation Hazard Zone B

Purification Methods

Wash the ester several times with water, redistil it using an efficient fractionating column at atmospheric pressure and a CaCl2 guard tube to keep free from moisture [Hamilton & Sly J Am Chem Soc 47 435 1925, Saunders et al. J Am Chem Soc 73 3796 1951]. [Beilstein 3 IV 23.] LACHRYMATORY AND TOXIC.


Highly flammable; Vapors may form explosive mixture with air. Emits fumes containing HCl on contact with moist air. Decomposes exothermically but slowly in water. Ethyl chloroformate decomposes slowly in water forming ethanol, hydrogen chloride and carbon dioxide. May react vigorously, possibly explosively, if mixed with di-isopropyl ether or other ethers in the presence of trace amounts of metal salts. Reacts with acids, alkalies, amines, alcohols, oxidizers and water. Corrosive to metals especially in the presence of moisture.

Waste Disposal

Use a licensed professional waste disposal service to dispose of this material. All federal, state, and local environmental regulations must be observed. Consult with environmental regulatory agencies for guidance on acceptable disposal practices

Ethyl chloroformate Preparation Products And Raw materials

Raw materials

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