1-(benzenesulfonyl)-4-bromo-6-fluoro-1H-indole synthesis
- Product Name:1-(benzenesulfonyl)-4-bromo-6-fluoro-1H-indole
- CAS Number:1001394-95-1
- Molecular formula:C14H9BrFNO2S
- Molecular Weight:354.19
885520-70-7
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1001394-95-1
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Yield:1001394-95-1 100%
Reaction Conditions:
with sodium hydroxide;tetra(n-butyl)ammonium hydrogensulfate in dichloromethane;water; for 1 h;
Steps:
36
Intermediate 36; 4-Bromo-6-fluoro-l-(phenylsulfonyl)-lH-indole; Aq. 4 M NaOH (5 mL) was added to a stirring mixture of 4-bromo-6-fluoro-lH-indole (500 mg, 2.34 mmol; Intermediate 35), benzenesulfonyl chloride (329 μL g, 2.57 mmol) and tetrabutylammonium hydrogen sulfate (78 mg, 0.23 mmol) in DCM (30 mL). The reaction mixture was stirred Ih, combined with an earlier batch of this intermediate (followed this experimental and starting with 4-bromo-6-fluoro-lH-indole, 152 mg, 0.71 mmol; Intermediate 35), washed twice with water, dried and concentrated. The product
References:
WO2008/3703,2008,A1 Location in patent:Page/Page column 91-92
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1001394-95-1
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