1-Benzyl-3-(5-methoxycarbonyl-2-furyl)indazole synthesis
- Product Name:1-Benzyl-3-(5-methoxycarbonyl-2-furyl)indazole
- CAS Number:170632-13-0
- Molecular formula:C20H16N2O3
- Molecular Weight:332.35
Yield:170632-13-0 78%
Reaction Conditions:
Stage #1: N-benzyl-3-iodo-1H-indazolewith diisopropyl zinc;lithium pentane-2,4-dionate in 1-methyl-pyrrolidin-2-one at 20; for 12 h;
Stage #2: methyl 5-bromo-2-furoatewith trifuran-2-yl-phosphane;bis(dibenzylideneacetone)-palladium(0) in tetrahydrofuran at 20; for 12 h;Negishi cross-coupling reaction;
References:
Gong, Liu-Zhu;Knochel, Paul [Synlett,2005,# 2,art. no. G41404ST,p. 267 - 270]
![2-Furancarboxylic acid, 5-[(Z)-phenyl[2-(phenylmethyl)hydrazinylidene]methyl]-, methyl ester](/CAS/20210305/GIF/377739-88-3.gif)
377739-88-3
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170632-13-0
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![2-Furancarboxylic acid, 5-[phenyl[2-(phenylmethyl)hydrazinylidene]methyl]-, methyl ester](/CAS/20210305/GIF/170632-18-5.gif)
170632-18-5
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