1-Boc-4-(Pyridazin-3-yl)piperazine synthesis
- Product Name:1-Boc-4-(Pyridazin-3-yl)piperazine
- CAS Number:492431-12-6
- Molecular formula:C13H20N4O2
- Molecular Weight:264.32
1120-95-2
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Yield:492431-12-6 31%
Reaction Conditions:
with potassium carbonate in 1-methyl-pyrrolidin-2-one at 120; for 16 h;
Steps:
133.1 Step 1: tert-Butyl 4-(pyridazin-3-yl)piperazine- 1-carboxylate
A mixture of 3-chloropyridazine (1 g, 8.73 mmol), tert-butyl piperazine-1-carboxylate(1.626 g, 8.73 mmol), and K2C03 (2.413 g, 17.46 mmol) in NMP (10 mL) was stirred at 120 °C for 16 h. The mixture was purified by chromatography (silica, EtOAc/PE =1/20) to afford tertbutyl 4-(pyridazin-3-yl)piperazine-1-carboxylate (709 mg, 2.68 mmol, 31%) as a yellow oil. ESIMS (EI+, m/z): 265.4 [M+H]t
References:
WO2018/89433,2018,A1 Location in patent:Paragraph 00911
492431-11-5
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