1-boc-5-broMo-3-Methyl-1h-pyrazolo[4,3-b]pyrazine synthesis
- Product Name:1-boc-5-broMo-3-Methyl-1h-pyrazolo[4,3-b]pyrazine
- CAS Number:1131041-61-6
- Molecular formula:C11H13BrN4O2
- Molecular Weight:313.15
24424-99-5
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![5-BroMo-3-Methyl-1H-pyrazolo[3,4-b]pyrazine](/CAS/GIF/1086064-35-8.gif)
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Yield: 68%
Reaction Conditions:
with dmap;triethylamine in dichloromethane at 20;
Steps:
1.h
Et3N (13 ml_, 2.0 eq.) was added to a solution of 1g (10g, 46.95 mmol), (Boc)2O (16.4 g, 1.6 eq.) and DMAP (280 mg, 5 mol%) in DCM (200 ml_). The resulting solution was stirred at rt overnight, concentrated and the residue was purified by flash column chromatography on silica gel (10% EtOAc/hexane) to give 10 g of 1h (68%) and some recovered starting material.
References:
SMITH KLINE BEECHAM CORPORATION WO2009/32653, 2009, A1 Location in patent:Page/Page column 9; 37
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1131041-58-1
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![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
1000210-73-0
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1131041-61-6
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