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1131041-61-6

1-boc-5-broMo-3-Methyl-1h-pyrazolo[4,3-b]pyrazine synthesis

4synthesis methods
24424-99-5 Synthesis
Di-tert-butyl dicarbonate

24424-99-5
863 suppliers
$13.50/25G

1-boc-5-broMo-3-Methyl-1h-pyrazolo[4,3-b]pyrazine

1131041-61-6
6 suppliers
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Yield: 68%

Reaction Conditions:

with dmap;triethylamine in dichloromethane at 20;

Steps:

1.h
Et3N (13 ml_, 2.0 eq.) was added to a solution of 1g (10g, 46.95 mmol), (Boc)2O (16.4 g, 1.6 eq.) and DMAP (280 mg, 5 mol%) in DCM (200 ml_). The resulting solution was stirred at rt overnight, concentrated and the residue was purified by flash column chromatography on silica gel (10% EtOAc/hexane) to give 10 g of 1h (68%) and some recovered starting material.

References:

SMITH KLINE BEECHAM CORPORATION WO2009/32653, 2009, A1 Location in patent:Page/Page column 9; 37