ChemicalBook CAS DataBase List 1-BROMO-2-BUTANOL

1-BROMO-2-BUTANOL synthesis

5synthesis methods

Product Name:1-BROMO-2-BUTANOL
CAS Number:2482-57-7
Molecular formula:C4H9BrO
Molecular Weight:153.02

558-13-4 Synthesis

558-13-4
251 suppliers
$10.00/1g

584-03-2
163 suppliers
$8.00/5g

2482-57-7
44 suppliers
$60.00/500mg

Yield: 90%

Reaction Conditions:

with triphenylphosphine in pyridine;ethyl acetate

Steps:

1.B B.
Carbontetrabromide (26.6 g, 80 mmol) and triphenylphosphine (21 g, 80 mmol) were added successively to 1,2-butanediol (7.2 g, 80 mmol) in anhydrous pyridine at 0° C., and the solution stirred at room temperature overnight. The mixture was concentrated and the residual oil dropwise added to vigorously stirred 1:5 ethyl acetate:hexanes (220 mL). The solution was decanted from the precipitate, concentrated, chromatographed (40 g silica gel, 1:3 ethyl acetate:hexanes), and gave GDLZ103 (11.5 g, 90%).

References:

GlycoDesign US6048870, 2000, A

106-88-7 Synthesis