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ChemicalBook CAS DataBase List 1-Cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxoq

1-Cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxoq synthesis

8synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 4 steps
1: tetrahydrofuran / 0.75 h / -78 °C
2: 1.) Ac2O / 1.) 150 deg C, 2 h, 2.) t-BuOH, 10 deg C, 30 min; 45 deg C, overnoght
3: t-BuOK / 2-methyl-propan-2-ol / 18 h / 50 °C
4: HCl / acetic acid / 2 h / 100 °C

References:

Domagala, John M.;Heifetz, Carl L.;Hutt, Marland P.;Mich, Thomas F.;Nichols, Jeffry B.;et al. [Journal of Medicinal Chemistry,1988,vol. 31,# 5,p. 991 - 1001]

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