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ChemicalBook CAS DataBase List 1-ethyl-1H-indole-5-carbaldehyde

1-ethyl-1H-indole-5-carbaldehyde synthesis

2synthesis methods
-

Yield:944893-74-7 91%

Reaction Conditions:

Stage #1: 1H-indole-5-carboxaldehydewith potassium carbonate in N,N-dimethyl-formamide at 20; for 0.166667 h;
Stage #2: ethyl iodide in N,N-dimethyl-formamide at 35; for 18 h;

References:

Bagnolini, Greta;Milano, Domenico;Manerba, Marcella;Schipani, Fabrizio;Ortega, Jose Antonio;Gioia, Dario;Falchi, Federico;Balboni, Andrea;Farabegoli, Fulvia;De Franco, Francesca;Robertson, Janet;Pellicciari, Roberto;Pallavicini, Isabella;Peri, Sebastiano;Minucci, Saverio;Girotto, Stefania;Di Stefano, Giuseppina;Roberti, Marinella;Cavalli, Andrea [Journal of Medicinal Chemistry,2020,vol. 63,# 5,p. 2588 - 2619] Location in patent:supporting information

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